{"id":"W4416410612","doi":"10.1038/s41467-025-65023-4","title":"An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Cambridge Institute for Medical Research, University of Cambridge; Medical Research Council; Wellcome Trust; UK Research and Innovation; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Mitochondrial DNA; Heteroplasmy; Lipopolysaccharide; Innate immune system; Mutation; Cytokine; Immune system; Macrophage; Mitochondrion","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003616531,0.0001448066,0.0002332896,0.0008318414,0.0001083979,0.00002392659,0.0005737245,0.0005685248,0.00002825401],"category_scores_gemma":[0.0005161598,0.0001521877,0.0000282259,0.0005373915,0.0002356692,0.0001938253,0.0002002045,0.001204672,0.000008340067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001114743,"about_ca_system_score_gemma":0.0001336196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002155773,"about_ca_topic_score_gemma":0.009883027,"domain_scores_codex":[0.9977411,0.001375207,0.0004237975,0.0002282315,0.00002464119,0.0002070105],"domain_scores_gemma":[0.9983895,0.000688376,0.00007355453,0.000769178,0.00006843094,0.0000109704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001879902,0.0002303279,0.006253695,0.00001310314,0.00001875198,0.000008035579,0.001375671,0.0000139056,0.9868031,0.002072948,0.0003306985,0.0009999154],"study_design_scores_gemma":[0.007087335,0.0001880642,0.562851,0.000586079,0.00002743813,0.00006583471,0.002247876,0.0004921135,0.3844999,0.0008198,0.04066494,0.0004695493],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813125,0.01569961,0.00001163083,0.001662739,0.0002354187,0.0003443118,0.00002833409,0.00003846424,0.0006669667],"genre_scores_gemma":[0.9974189,0.0008786279,0.0004159099,0.0003324496,0.000005649755,0.00006755635,0.00008857145,0.00001081341,0.000781477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6023031,"threshold_uncertainty_score":0.6206034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01068190908147577,"score_gpt":0.3008685715835612,"score_spread":0.2901866625020854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}