{"id":"W4416411047","doi":"10.1016/j.celrep.2025.116582","title":"Mechanisms of chemokine recognition and receptor activation of chemokine receptor CCR7","year":2025,"lang":"en","type":"article","venue":"Cell Reports","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Youth Innovation Promotion Association of the Chinese Academy of Sciences; Science and Technology Commission of Shanghai Municipality; National Natural Science Foundation of China; National Key Research and Development Program of China; Canadian Anesthesiologists' Society; Shanghai Lingjun Program; China Association for Science and Technology","keywords":"CCL19; CCL21; C-C chemokine receptor type 7; CCR1; Chemokine receptor; C-C chemokine receptor type 6; Chemokine receptor CCR5; XCL2; CC chemokine receptors","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003910215,0.0002994002,0.0002613669,0.0002942308,0.0003303177,0.0006798785,0.0006488168,0.0006893714,0.001490816],"category_scores_gemma":[0.0002217307,0.000165187,0.000345941,0.0001494508,0.0005476139,0.0006162217,0.0004543671,0.0005832393,0.0006001673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005868272,"about_ca_system_score_gemma":0.0003314837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005777301,"about_ca_topic_score_gemma":0.0005631263,"domain_scores_codex":[0.9996005,0.0001165561,0.00001373052,0.0000366729,0.000116952,0.0001156705],"domain_scores_gemma":[0.9999024,0.00001938929,0.00002293246,0.000009258662,0.00002305359,0.00002312266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002245944,0.00004640942,0.001022287,0.0002577329,0.00002954881,0.0006764148,0.0001747377,0.001243357,0.959873,0.02433982,0.0009780913,0.01113405],"study_design_scores_gemma":[0.000183214,0.001013652,0.01392699,0.0001665845,0.00006372001,0.004216124,0.0008908985,0.02534427,0.8899637,0.01385345,0.05027548,0.0001018204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8984982,0.03996104,0.03884234,0.002879157,0.0002033398,0.0002016876,0.0002447603,0.000245544,0.01892401],"genre_scores_gemma":[0.9842015,0.008071162,0.004217964,0.0004486956,0.00005587567,0.00006856615,0.0001657058,0.00001340438,0.002757124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001490816,"threshold_uncertainty_score":0.00498724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01507508920416302,"score_gpt":0.2418565608832741,"score_spread":0.2267814716791111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}