{"id":"W4416413126","doi":"10.3390/ijms262211221","title":"Untargeted Metabolomics Identifies Faecal Filtrate-Derived Metabolites That Disrupt Clostridioides difficile Metabolism and Confer Gut Barrier Cytoprotection","year":2025,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Metabolomics; Metabolite; Metabolome; Cytoprotection; Metabolic pathway; Lipidomics; Metabolism; Glutamine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001517466,0.0004326354,0.0003450926,0.0003912943,0.000203709,0.0004669696,0.000149433,0.0004886001,0.001242206],"category_scores_gemma":[0.0001588778,0.000162824,0.0003150958,0.0002463486,0.0002486759,0.0002187648,0.0003866031,0.0005719368,0.0002964016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002961041,"about_ca_system_score_gemma":0.0002657375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000852189,"about_ca_topic_score_gemma":0.001665929,"domain_scores_codex":[0.999868,0.00001412496,0.00000611896,0.00003359707,0.00004069707,0.0000374608],"domain_scores_gemma":[0.9999185,0.00000997293,0.00002724565,0.000006585,0.00001712542,0.00002056674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004334686,0.00002481124,0.002477597,0.00007459785,0.00001845652,0.0001599365,0.00003169118,0.0001014762,0.9918057,0.0000350934,0.0001617881,0.004675486],"study_design_scores_gemma":[0.00004600715,0.001606151,0.1111522,0.00005546039,0.0001354881,0.002415894,0.0004231297,0.003009727,0.873154,0.0004025542,0.007556319,0.00004299779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891384,0.002543386,0.004768544,0.0003221975,0.00006467456,0.00004490283,0.001910193,0.0002007682,0.001006904],"genre_scores_gemma":[0.9874091,0.001748399,0.006090704,0.0003795331,0.00002191593,0.00006307122,0.002067799,0.00008371411,0.002135841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001242206,"threshold_uncertainty_score":0.004155636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02189169756914575,"score_gpt":0.3160827862671912,"score_spread":0.2941910886980454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}