{"id":"W4416420084","doi":"10.2139/ssrn.5772626","title":"Identification of Computationally Designed Skeletal and Cardiac Promoters with High Specificity Across AAV Delivery Routes","year":2025,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"","keywords":"Promoter; Transgene; Gene expression; Capsid; Genetic enhancement; Reporter gene; Gene; Genome; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006342152,0.0005269618,0.0006861355,0.000261612,0.0002553276,0.0008289907,0.0004903023,0.0004776758,0.001888792],"category_scores_gemma":[0.001120693,0.0003218192,0.0004763285,0.0002567216,0.0002568602,0.0002682446,0.0003540586,0.0007915488,0.001360334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007015373,"about_ca_system_score_gemma":0.0009536503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005066579,"about_ca_topic_score_gemma":0.001371361,"domain_scores_codex":[0.999665,0.00006052049,0.00002147696,0.00007992538,0.0001267936,0.00004623507],"domain_scores_gemma":[0.9996721,0.0001406948,0.0000567208,0.00003453067,0.00005442072,0.00004158574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0006140731,0.0001873798,0.001061094,0.0003342713,0.00003899716,0.0002317922,0.00005801739,0.03714357,0.9284365,0.004027538,0.00072132,0.02714544],"study_design_scores_gemma":[0.0001168489,0.0004000286,0.0005936453,0.00002303589,0.00006129024,0.0002464726,0.00003935202,0.1298405,0.8615807,0.001075793,0.005989653,0.00003270606],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7569337,0.001084945,0.2314088,0.000238829,0.0001119431,0.0002349515,0.0007280661,0.00208995,0.007168708],"genre_scores_gemma":[0.8219556,0.0006304818,0.1708018,0.00009657646,0.00001590166,0.0002466451,0.001849591,0.0005837429,0.003819677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001888792,"threshold_uncertainty_score":0.006318629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008236680806186027,"score_gpt":0.2766464239736424,"score_spread":0.2684097431674564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}