{"id":"W4416420629","doi":"10.1016/j.isci.2025.114085","title":"Lithium attenuates HIV-1 latency reversal in an autophagy-independent way","year":2025,"lang":"en","type":"article","venue":"iScience","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Lithium (medication); Autophagy; Primary cell; Virus; Latency (audio); Lithium therapy; Drug repositioning","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001005005,0.0003353172,0.0004784892,0.0002392375,0.0002066397,0.0004501473,0.0003793515,0.00046435,0.003941249],"category_scores_gemma":[0.0001388453,0.00009841056,0.0002539929,0.0001597091,0.0002763544,0.000328787,0.0001937718,0.0008248841,0.0007038641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003365428,"about_ca_system_score_gemma":0.0006103727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001081729,"about_ca_topic_score_gemma":0.00247597,"domain_scores_codex":[0.9998744,0.00002305536,0.00001653962,0.00001260992,0.00003039749,0.00004299822],"domain_scores_gemma":[0.9999212,0.000016263,0.000016849,0.00001166368,0.0000125901,0.00002141617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002789363,0.0008000537,0.000517091,0.000300575,0.00002993979,0.0001520454,0.00007633634,0.0001145483,0.9751788,0.0007186934,0.001242445,0.01808014],"study_design_scores_gemma":[0.0001934374,0.00327742,0.004857472,0.00003153574,0.00005260122,0.0002872739,0.0001006738,0.0006972608,0.9808908,0.000251103,0.009344098,0.00001640842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9704149,0.008535299,0.002493842,0.0009067149,0.0003888721,0.0001571848,0.002406547,0.0008835507,0.01381293],"genre_scores_gemma":[0.9842191,0.002238933,0.001515182,0.0001859753,0.00005155923,0.00009105142,0.0008996935,0.00003091594,0.01076771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003941249,"threshold_uncertainty_score":0.01318473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01473003859113881,"score_gpt":0.2878227638225644,"score_spread":0.2730927252314256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}