{"id":"W4416424919","doi":"10.1016/j.matbio.2025.11.006","title":"High hyaluronan binding and RHAMM expression identify an invasive and metastatic subpopulation in androgen-resistant prostate cancer cells","year":2025,"lang":"en","type":"article","venue":"Matrix Biology","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Prostate Cancer Canada; Worldwide Cancer Research; Elsa U. Pardee Foundation; U.S. Department of Defense","keywords":"Prostate cancer; CD44; Flow cytometry; Motility; Transcriptome; Tumor progression; Extracellular matrix; Cancer; Cancer cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002770503,0.0001614662,0.0002142003,0.0001984386,0.0001043354,0.00004516934,0.0001177002,0.0001435507,0.00001357692],"category_scores_gemma":[0.00005270189,0.0001394318,0.0000237844,0.0001607914,0.0001327904,0.00001218808,0.0001968041,0.0001112501,0.000001102623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002704637,"about_ca_system_score_gemma":0.0001072625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001385342,"about_ca_topic_score_gemma":0.002030385,"domain_scores_codex":[0.9986805,0.0002030456,0.0002481096,0.0004920977,0.00006487907,0.0003113956],"domain_scores_gemma":[0.9995699,0.00002833331,0.00007207932,0.0002038252,0.00004852624,0.0000773512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002775873,0.0000311165,0.03324691,0.000087116,0.00002349188,0.000009253476,0.00006677214,0.00001989685,0.9610507,0.0001680847,0.00004977863,0.004969322],"study_design_scores_gemma":[0.001542675,0.0005300217,0.02865211,0.00007999613,0.00002292237,0.00000648501,0.0002078573,0.0001386306,0.9657955,0.001056354,0.001729519,0.0002379329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954954,0.003502067,0.0001314497,0.0001618681,0.0001022716,0.0004587464,0.0001226424,0.000008006759,0.0000175365],"genre_scores_gemma":[0.9973046,0.001265949,0.0006127289,0.00005507698,0.0000294162,0.0001111637,0.0002240936,0.00001277193,0.0003842282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004744826,"threshold_uncertainty_score":0.5685865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01419371983397193,"score_gpt":0.3369871250119746,"score_spread":0.3227934051780026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}