{"id":"W4416427829","doi":"10.1016/j.omtn.2025.102780","title":"mRNA-LNP vaccination orchestrates systemic immunity to control human papillomavirus-positive head and neck squamous cell carcinoma","year":2025,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Princess Margaret Cancer Centre","funders":"Chengdu Science and Technology Program; National Key Research and Development Program of China; National Key Research and Development Program of China Stem Cell and Translational Research; Sichuan University; Chengdu Science and Technology Bureau; West China Hospital, Sichuan University; Department of Science and Technology of Sichuan Province; National Natural Science Foundation of China","keywords":"Immune system; Vaccination; Immunotherapy; Head and neck squamous-cell carcinoma; Innate immune system; Immunity; Acquired immune system; Tumor microenvironment","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001731707,0.0003060873,0.0002820786,0.0001166561,0.0002155523,0.00008933432,0.0003278322,0.0002332036,0.0000201009],"category_scores_gemma":[0.00002041019,0.0003006792,0.0001293896,0.0001609517,0.00004828878,0.00001051916,0.0001061489,0.0001626553,0.00001775116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004411974,"about_ca_system_score_gemma":0.00006726841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001931621,"about_ca_topic_score_gemma":0.00002451816,"domain_scores_codex":[0.9985272,0.0002106565,0.0003025364,0.000499422,0.0001313425,0.0003288922],"domain_scores_gemma":[0.9990903,0.00001648209,0.00008606711,0.0005169897,0.0001830908,0.0001070984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003591946,0.0001102452,0.007646632,0.00002899348,0.00007528969,0.00001905162,0.0001789274,0.00004602614,0.9858988,0.0001085364,0.0002404677,0.005287831],"study_design_scores_gemma":[0.002907998,0.001475638,0.07405077,0.0000413194,0.00004007294,0.00001779244,0.0002095078,0.00006443486,0.9196428,0.000154098,0.001039661,0.0003558919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899971,0.004779858,0.002358827,0.0001863182,0.0001030788,0.0005924289,0.00002954727,0.00002722317,0.001925585],"genre_scores_gemma":[0.9970895,0.0001807085,0.0001003281,0.001864321,0.00005349452,0.00006549117,0.00009061499,0.00003575388,0.0005197961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06640413,"threshold_uncertainty_score":0.9999445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007849051683796512,"score_gpt":0.2514146929450725,"score_spread":0.2435656412612759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}