{"id":"W4416427829","doi":"10.1016/j.omtn.2025.102780","title":"mRNA-LNP vaccination orchestrates systemic immunity to control human papillomavirus-positive head and neck squamous cell carcinoma","year":2025,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Princess Margaret Cancer Centre","funders":"Chengdu Science and Technology Program; National Key Research and Development Program of China; National Key Research and Development Program of China Stem Cell and Translational Research; Sichuan University; Chengdu Science and Technology Bureau; West China Hospital, Sichuan University; Department of Science and Technology of Sichuan Province; National Natural Science Foundation of China","keywords":"Immune system; Vaccination; Immunotherapy; Head and neck squamous-cell carcinoma; Innate immune system; Immunity; Acquired immune system; Tumor microenvironment","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009359146,0.0001643789,0.0001873219,0.0000877055,0.00007198592,0.0001883916,0.00007114704,0.0001299011,0.0005218103],"category_scores_gemma":[0.0000657604,0.0000661052,0.0001143746,0.00005172492,0.0001714495,0.0001379687,0.000128342,0.0002516583,0.0001581057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002402268,"about_ca_system_score_gemma":0.0001851638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002629511,"about_ca_topic_score_gemma":0.0004579498,"domain_scores_codex":[0.9999186,0.000009733505,0.000004089699,0.00002310783,0.00002163907,0.00002280298],"domain_scores_gemma":[0.9999748,0.000003969581,0.000008129608,0.000002739728,0.000004964916,0.000005331588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002452287,0.000007803791,0.00009250653,0.00001404496,8.0953e-7,0.000008629183,0.000005593844,0.0001050011,0.9985017,0.00005474421,0.00001357915,0.001171106],"study_design_scores_gemma":[0.000007657532,0.0002949846,0.002300113,0.000004144431,0.000009255739,0.00006721366,0.00002460963,0.00372568,0.9917795,0.0000703417,0.001713632,0.000002796051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880813,0.0009336448,0.009113375,0.00006354103,0.00003463764,0.00005340184,0.0001000638,0.0001315469,0.001488452],"genre_scores_gemma":[0.9956553,0.0003858366,0.002607149,0.00004352268,0.000007177575,0.00003599753,0.00007318502,0.00002102962,0.001170906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005218103,"threshold_uncertainty_score":0.001745641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007849051683796512,"score_gpt":0.2514146929450725,"score_spread":0.2435656412612759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}