{"id":"W4416430934","doi":"10.1126/science.aee0352","title":"‘A sigh of relief’: New malaria drug succeeds in clinical trial as existing treatments falter","year":2025,"lang":"en","type":"article","venue":"Science","topic":"Malaria Research and Control","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Public Health","funders":"","keywords":"Clinical trial; Drug trial; Drug; Drug development; Malaria; Clinical research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04244668,0.001691161,0.002405703,0.001320741,0.003889112,0.009443094,0.001869839,0.01650269,0.02114614],"category_scores_gemma":[0.1129544,0.001143438,0.001804491,0.001180393,0.01380892,0.01806865,0.004784951,0.02620209,0.0136434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00308067,"about_ca_system_score_gemma":0.003571205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001951675,"about_ca_topic_score_gemma":0.004059451,"domain_scores_codex":[0.9706086,0.01233244,0.002824338,0.003550949,0.009061572,0.001622104],"domain_scores_gemma":[0.9404008,0.03195658,0.006258102,0.005254739,0.01010647,0.006023198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.0006898317,0.0000752351,0.0009516819,0.0006706217,0.0001360688,0.0003993002,0.0005004414,0.0001085286,0.001526702,0.0195058,0.8628102,0.1126255],"study_design_scores_gemma":[0.0004941394,0.0007930785,0.002379271,0.001119342,0.0001256345,0.002009894,0.0005888889,0.0007090672,0.001498291,0.03422223,0.9558315,0.0002285866],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.003097782,0.03821065,0.006073065,0.8700386,0.0624348,0.0001242612,0.0003271713,0.001079518,0.01861428],"genre_scores_gemma":[0.04113759,0.01951605,0.01005525,0.8510084,0.05318919,0.0001393268,0.000343854,0.0008104498,0.02379986],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.04244668,"threshold_uncertainty_score":0.2244821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06591020921261877,"score_gpt":0.4481919795706791,"score_spread":0.3822817703580604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}