{"id":"W4416434732","doi":"10.1021/acsestwater.5c00698","title":"Oil Sands Process Water and Naphthenic Acids Activate Mammalian Macrophages via a Toll-Like Receptor 4 (TLR4)-Dependent Mechanism","year":2025,"lang":"en","type":"article","venue":"ACS ES&T Water","topic":"Petroleum Processing and Analysis","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"EPCOR; Canadian Institutes of Health Research; Canada First Research Excellence Fund; Alberta Innovates; Natural Sciences and Engineering Research Council of Canada; Canada's Oil Sands Innovation Alliance; Imperial Oil Limited; Syncrude; Canadian Natural Resources Limited; Teck Resources; Alberta Environment and Parks; Suncor Energy Incorporated","keywords":"TLR4; Jurkat cells; Proinflammatory cytokine; Immune system; Receptor; Oil sands; Macrophage; Monocyte","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002462081,0.0004301353,0.0004604264,0.0001770144,0.0003594727,0.0002743519,0.0004341876,0.0002980334,0.001297556],"category_scores_gemma":[0.00001094522,0.0002676933,0.0001385904,0.0001226713,0.00009171575,0.0002701685,0.0002633327,0.000367869,0.0001382433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007824659,"about_ca_system_score_gemma":0.00003241427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003877162,"about_ca_topic_score_gemma":0.00000862127,"domain_scores_codex":[0.9977068,0.00003917557,0.0003994193,0.0007444217,0.0003570563,0.0007531147],"domain_scores_gemma":[0.9991848,0.00001836789,0.00006870212,0.0004843859,0.00009658931,0.000147171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001308166,0.00008778222,0.000522701,0.0005691092,0.0002807968,0.00003861235,0.0009488859,0.000007643611,0.9827692,0.0000158651,0.0001189509,0.01450964],"study_design_scores_gemma":[0.0009637617,0.00002102269,0.000008863562,0.000146473,0.0002031284,0.000025692,0.0002674546,0.0001314708,0.9849697,0.0007978043,0.01205441,0.0004102563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921182,0.0002007829,0.0001462628,0.001275263,0.0001585537,0.00001103785,0.00002223452,0.0001893669,0.005878313],"genre_scores_gemma":[0.8403347,0.00007442913,0.00009283464,0.0003387134,0.0001188896,0.00004635603,0.0001125267,0.00004615561,0.1588354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.152957,"threshold_uncertainty_score":0.9999775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005271090739979266,"score_gpt":0.2283584031521945,"score_spread":0.2230873124122152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}