{"id":"W4416434732","doi":"10.1021/acsestwater.5c00698","title":"Oil Sands Process Water and Naphthenic Acids Activate Mammalian Macrophages via a Toll-Like Receptor 4 (TLR4)-Dependent Mechanism","year":2025,"lang":"en","type":"article","venue":"ACS ES&T Water","topic":"Petroleum Processing and Analysis","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"EPCOR; Canadian Institutes of Health Research; Canada First Research Excellence Fund; Alberta Innovates; Natural Sciences and Engineering Research Council of Canada; Canada's Oil Sands Innovation Alliance; Imperial Oil Limited; Syncrude; Canadian Natural Resources Limited; Teck Resources; Alberta Environment and Parks; Suncor Energy Incorporated","keywords":"TLR4; Jurkat cells; Proinflammatory cytokine; Immune system; Receptor; Oil sands; Macrophage; Monocyte","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001393779,0.0004596326,0.0002122295,0.0001727128,0.0001192022,0.0001830115,0.0001305047,0.0003375175,0.001244202],"category_scores_gemma":[0.0001136669,0.0001453967,0.0003755823,0.0001000126,0.0001794212,0.0001967424,0.0003130357,0.0002509254,0.0002771163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001754007,"about_ca_system_score_gemma":0.0002380625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004517944,"about_ca_topic_score_gemma":0.0006355264,"domain_scores_codex":[0.9997937,0.00004970604,0.00001548626,0.00002945586,0.00005879804,0.00005285738],"domain_scores_gemma":[0.9999465,0.000008098139,0.00002236363,0.00000431566,0.00001043226,0.000008157966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001214744,0.00001966622,0.0003054934,0.00005288221,0.00000809347,0.00005859888,0.000009492946,0.00006399865,0.9981526,0.00003539208,0.00001513993,0.001157263],"study_design_scores_gemma":[0.00001310123,0.0004495396,0.002967567,0.000005298912,0.00001363741,0.0001405783,0.00004560602,0.0005411538,0.9946522,0.00005969212,0.001107962,0.000003847382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926338,0.001682559,0.003848482,0.00008727339,0.00002383889,0.00006120421,0.0001719268,0.0000348642,0.001456204],"genre_scores_gemma":[0.9921914,0.001219625,0.003145569,0.0001047539,0.0000152102,0.00008883738,0.0002279922,0.00000663955,0.003000011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001244202,"threshold_uncertainty_score":0.004162192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005271090739979266,"score_gpt":0.2283584031521945,"score_spread":0.2230873124122152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}