{"id":"W4416438655","doi":"10.1016/j.ijrobp.2025.08.061","title":"“Adaptive” Radiation Therapy to Widen the Therapeutic Window","year":2025,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Effects of Radiation Exposure","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Merck","keywords":"Radiation therapy; Window (computing); Therapeutic window; Radiation dose; Radiation injury","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003681407,0.0003749234,0.0003440554,0.0003217566,0.0002707971,0.0006295273,0.0006170365,0.0005024339,0.005544317],"category_scores_gemma":[0.0007046671,0.0001985761,0.0005385667,0.0002763607,0.0004257908,0.0009806714,0.0007796457,0.001207496,0.0008700267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000287534,"about_ca_system_score_gemma":0.0003434254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002273269,"about_ca_topic_score_gemma":0.0004084134,"domain_scores_codex":[0.999832,0.00002793963,0.000009880529,0.00005688151,0.00004306946,0.00003019526],"domain_scores_gemma":[0.9998392,0.00006301775,0.00003529508,0.00002998021,0.00001638084,0.00001623288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001619069,0.0007308767,0.004644234,0.0008749531,0.0002747633,0.0003975632,0.0004077576,0.01670642,0.6620173,0.019075,0.007433067,0.2858189],"study_design_scores_gemma":[0.0006822662,0.005322332,0.02817739,0.0004558094,0.000939213,0.008558359,0.0004282076,0.07831215,0.6304281,0.03569645,0.2107461,0.0002536758],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3441285,0.03819214,0.5650763,0.005251216,0.002081084,0.0003427649,0.000400012,0.00373281,0.04079519],"genre_scores_gemma":[0.9221032,0.006329373,0.0604088,0.002679109,0.0004876294,0.0001636197,0.0001720182,0.0005988666,0.007057429],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005544317,"threshold_uncertainty_score":0.01854753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0203811478178637,"score_gpt":0.3499737453889708,"score_spread":0.3295925975711071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}