{"id":"W4416438981","doi":"10.1111/liv.70423","title":"Elevated Serum Bile Acids Predict Poor Liver Outcomes in Children With Alagille Syndrome: Results From the <scp>GALA</scp> Study Group","year":2025,"lang":"en","type":"article","venue":"Liver International","topic":"Pediatric Hepatobiliary Diseases and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Health Services and Policy Research; Children's Hospital of Eastern Ontario; University of Manitoba; Western University; Hospital for Sick Children; Toronto General Hospital; University Health Network; University of Toronto; Children's Hospital of Western Ontario; London Health Sciences Centre","funders":"Cliniques Universitaires Saint-Luc; University of Colorado School of Medicine, Anschutz Medical Campus; School of Medicine, Emory University; Uniwersytet Śląski w Katowicach; Ipsen; Śląski Uniwersytet Medyczny w Katowicach; Assistance publique-Hôpitaux de Paris; Université Paris-Saclay; Université de Genève; Universitair Medisch Centrum Groningen; Hospital for Sick Children; School of Medicine, Stanford University; Fudan University; Perelman School of Medicine, University of Pennsylvania; University of Ulsan; Karolinska Institutet; Institut National de la Santé et de la Recherche Médicale; University of Washington; Audentes Therapeutics; Horizon Pharmaceuticals; Ipsen Biopharmaceuticals; Danone; Children's Healthcare of Atlanta; University of Pennsylvania; Seattle Children's Research Institute; Virginia Commonwealth University; National Natural Science Foundation of China; Alagille Syndrome Alliance; University of Pittsburgh; Alexion Pharmaceuticals; University of Toronto; Emory University; National Center for Child Health and Development; Children's Hospital of Philadelphia","keywords":"Alagille syndrome; Bile acid; Cholestasis; Liver disease; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001464015,0.0002297994,0.0002851695,0.0001727911,0.00007966297,0.00004512863,0.0003185591,0.00007473582,0.0001492219],"category_scores_gemma":[0.0002335386,0.0001414709,0.0001059529,0.0003052595,0.00005539775,0.0001555811,0.0001654532,0.0002234197,0.00007823965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001678973,"about_ca_system_score_gemma":0.0001227766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00376359,"about_ca_topic_score_gemma":0.0003875985,"domain_scores_codex":[0.9982672,0.0000855292,0.0003732799,0.0004774068,0.0005561076,0.000240414],"domain_scores_gemma":[0.998965,0.0003739096,0.00009852775,0.0003645972,0.00009824075,0.00009969392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001498023,0.002121472,0.9903533,0.00000404305,0.001684103,0.000367195,0.000326222,0.00001197796,0.000003126762,0.00002199022,0.004629132,0.0003276753],"study_design_scores_gemma":[0.009020586,0.0003995402,0.9881449,0.00007604928,0.0004332405,0.00003051125,0.0003765327,0.0006152615,0.000009901926,0.00002483426,0.000814668,0.00005392243],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946656,0.0001896414,0.00001051781,0.0006637551,0.0002285874,0.001130466,0.001573752,0.00007037645,0.001467323],"genre_scores_gemma":[0.9940643,0.0001231443,0.00008176141,0.0007436444,0.00009501119,0.0001062944,0.0008746194,0.00001757227,0.003893596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008870783,"threshold_uncertainty_score":0.5769016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008038082742084078,"score_gpt":0.243541687535002,"score_spread":0.2355036047929179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}