{"id":"W4416438981","doi":"10.1111/liv.70423","title":"Elevated Serum Bile Acids Predict Poor Liver Outcomes in Children With Alagille Syndrome: Results From the <scp>GALA</scp> Study Group","year":2025,"lang":"en","type":"article","venue":"Liver International","topic":"Pediatric Hepatobiliary Diseases and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Health Services and Policy Research; Children's Hospital of Eastern Ontario; University of Manitoba; Western University; Hospital for Sick Children; Toronto General Hospital; University Health Network; University of Toronto; Children's Hospital of Western Ontario; London Health Sciences Centre","funders":"Cliniques Universitaires Saint-Luc; University of Colorado School of Medicine, Anschutz Medical Campus; School of Medicine, Emory University; Uniwersytet Śląski w Katowicach; Ipsen; Śląski Uniwersytet Medyczny w Katowicach; Assistance publique-Hôpitaux de Paris; Université Paris-Saclay; Université de Genève; Universitair Medisch Centrum Groningen; Hospital for Sick Children; School of Medicine, Stanford University; Fudan University; Perelman School of Medicine, University of Pennsylvania; University of Ulsan; Karolinska Institutet; Institut National de la Santé et de la Recherche Médicale; University of Washington; Audentes Therapeutics; Horizon Pharmaceuticals; Ipsen Biopharmaceuticals; Danone; Children's Healthcare of Atlanta; University of Pennsylvania; Seattle Children's Research Institute; Virginia Commonwealth University; National Natural Science Foundation of China; Alagille Syndrome Alliance; University of Pittsburgh; Alexion Pharmaceuticals; University of Toronto; Emory University; National Center for Child Health and Development; Children's Hospital of Philadelphia","keywords":"Alagille syndrome; Bile acid; Cholestasis; Liver disease; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001087558,0.0006155153,0.0005491067,0.0007618425,0.000359343,0.0008410993,0.0004084469,0.000515017,0.001474326],"category_scores_gemma":[0.00219732,0.000296468,0.00110674,0.000869594,0.0004278003,0.0003593731,0.0008652713,0.0007271857,0.0002602055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003294469,"about_ca_system_score_gemma":0.0003829574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004071404,"about_ca_topic_score_gemma":0.003781484,"domain_scores_codex":[0.999551,0.0001573384,0.00005275618,0.0001181225,0.00006353798,0.0000572534],"domain_scores_gemma":[0.9982669,0.0004574072,0.0006492728,0.0001784409,0.0001482961,0.0002996502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002331369,0.00001339184,0.998605,0.0000100588,0.000114421,0.00008145168,0.00004296781,0.00004061799,0.0001008233,0.0000118333,0.0001232219,0.000623119],"study_design_scores_gemma":[0.00005444008,0.0001649221,0.9984762,0.00001584824,0.0001655215,0.000482547,0.0001508731,0.0001872475,0.00005583775,0.0000303325,0.0002103327,0.000005916183],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989271,0.0002466527,0.00006448376,0.00005795377,0.00000507277,0.000007092797,0.0005166036,0.000003748382,0.000171228],"genre_scores_gemma":[0.9984043,0.0001896265,0.00009285618,0.00003728032,0.00001774845,0.00001733415,0.00113181,0.000004309834,0.0001046996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004071404,"threshold_uncertainty_score":0.008095443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008038082742084078,"score_gpt":0.243541687535002,"score_spread":0.2355036047929179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}