{"id":"W4416446323","doi":"10.1093/jimmun/vkaf283.1408","title":"Cytotoxic CD4 T cells in acute and chronic viral infection 3631","year":2025,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Cytotoxic T cell; Immune system; Cytolysis; Chronic infection; CD8; Immunity; T cell; Cytotoxicity; Interleukin 21","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002817935,0.0002254557,0.0001761538,0.0005052694,0.0002222357,0.0003394264,0.000170259,0.0004304756,0.002546456],"category_scores_gemma":[0.0002359886,0.0001019628,0.00009448063,0.0001363731,0.0002838084,0.0002406082,0.0003024972,0.0004719853,0.0003391784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003236027,"about_ca_system_score_gemma":0.0001948557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002577271,"about_ca_topic_score_gemma":0.000185281,"domain_scores_codex":[0.9998609,0.00002358257,0.00001626025,0.00002421196,0.00001861604,0.00005652867],"domain_scores_gemma":[0.9998621,0.00002693033,0.00002652353,0.00001368203,0.00001820595,0.00005251304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004958604,0.0006817658,0.08125288,0.0004458713,0.00004899717,0.003105896,0.0004247287,0.0003562857,0.8429362,0.002400222,0.001520124,0.06186835],"study_design_scores_gemma":[0.001384718,0.01259554,0.6080845,0.0003871917,0.0002727005,0.03162466,0.001306371,0.005705929,0.2548041,0.005875624,0.07787152,0.00008711602],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987359,0.006758315,0.0008401599,0.0001291213,0.00004946434,0.00005348544,0.0001971723,0.00003659612,0.004576793],"genre_scores_gemma":[0.995349,0.0009096198,0.0003575594,0.0001039365,0.00005506313,0.00006192627,0.0003310386,0.000003531895,0.002828409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002546456,"threshold_uncertainty_score":0.008518755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005032517673188532,"score_gpt":0.2321240210593505,"score_spread":0.2270915033861619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}