{"id":"W4416446676","doi":"10.1093/jimmun/vkaf283.1322","title":"IRF2 expression in Tregs limits the antiviral immune response to prevent mortality during chronic infection 3529","year":2025,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"CD8; Immune system; Chronic infection; Immunotherapy; Cytotoxic T cell; T cell; Conditional gene knockout; Effector","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001760958,0.0002701763,0.0002798095,0.0001856182,0.0001414037,0.0002844892,0.0001932994,0.0002652566,0.001662207],"category_scores_gemma":[0.0001087363,0.000104923,0.0002393863,0.00007422856,0.0002266387,0.0001951552,0.0002072286,0.0007989309,0.0004318136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001815884,"about_ca_system_score_gemma":0.000200307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002235272,"about_ca_topic_score_gemma":0.0003972875,"domain_scores_codex":[0.9998528,0.00001679603,0.00001378511,0.00002896519,0.00003223585,0.00005545289],"domain_scores_gemma":[0.9998671,0.00001256985,0.00003674476,0.00001723058,0.00001433699,0.00005202728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001855303,0.0000492716,0.0004150991,0.00002102501,0.000002615681,0.00001857359,0.000007931047,0.00004826361,0.9976193,0.00007750942,0.00006396652,0.001490909],"study_design_scores_gemma":[0.00005955574,0.001232606,0.00814632,0.00001628201,0.00002748313,0.0003091879,0.00005988105,0.001442407,0.9853529,0.0001382543,0.003206122,0.000008966696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944705,0.0008672994,0.003033574,0.0001148116,0.00004174506,0.00002481218,0.0002517574,0.00009608889,0.001099479],"genre_scores_gemma":[0.9957327,0.0003123716,0.001500305,0.00006319545,0.00001904841,0.00003460243,0.0002496329,0.00002220562,0.002066002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001662207,"threshold_uncertainty_score":0.005560577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01071054043182862,"score_gpt":0.2601373148594384,"score_spread":0.2494267744276097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}