{"id":"W4416446808","doi":"10.1093/jimmun/vkaf283.1249","title":"Development and preclinical validation of a therapeutic γδ TCR-engineered cell product for pan-cancer targeting 3442","year":2025,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Canadian Institutes of Health Research","keywords":"T-cell receptor; Chimeric antigen receptor; Antigen; Population; T cell; Adoptive cell transfer; CRISPR; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008070651,0.0003950532,0.0002509534,0.0003095599,0.0002146207,0.000561273,0.0003567929,0.0005257895,0.001742341],"category_scores_gemma":[0.000297687,0.0001764907,0.000246347,0.0001920599,0.000228074,0.0001987371,0.0001808176,0.0007391133,0.0007885044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000454604,"about_ca_system_score_gemma":0.0006991113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001301223,"about_ca_topic_score_gemma":0.0009032665,"domain_scores_codex":[0.9994302,0.00008856857,0.0000359224,0.00008146226,0.0003003752,0.00006335387],"domain_scores_gemma":[0.9997533,0.00002736323,0.00003551946,0.00004506266,0.00008951744,0.00004926622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001035059,0.0001805117,0.0001265735,0.00003858483,0.000007384776,0.00004565944,0.0000254427,0.0007931996,0.9941907,0.0002487182,0.000233772,0.004006127],"study_design_scores_gemma":[0.00004489077,0.001968792,0.0007414751,0.00001053347,0.00002470734,0.0001580476,0.00001746934,0.001816912,0.9867635,0.00004698526,0.008401237,0.000005387445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9343622,0.002173179,0.04898415,0.0003166778,0.0001837323,0.001647038,0.00196378,0.0003714127,0.00999783],"genre_scores_gemma":[0.9569121,0.001393086,0.02700204,0.0001510744,0.00001912071,0.0005812375,0.002683154,0.00008483173,0.01117334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001742341,"threshold_uncertainty_score":0.005828679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05388783730068482,"score_gpt":0.3671076135907055,"score_spread":0.3132197762900207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}