{"id":"W4416447155","doi":"10.1093/jimmun/vkaf283.2120","title":"Immune Cell Profiling in Clinical Sepsis: Insights from scRNA-seq Meta-Analysis of publicly available datasets 4438","year":2025,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"American Association of Immunologists","keywords":"Immune system; Sepsis; Peripheral blood mononuclear cell; Acquired immune system; Innate immune system; CD14; Dendritic cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch","metaepi_broad"],"consensus_categories":[],"category_scores_codex":[0.007846146,0.001159875,0.002688647,0.00394241,0.0007811245,0.002404687,0.001475225,0.0009409716,0.003648548],"category_scores_gemma":[0.01634208,0.0004853454,0.005697368,0.004102685,0.0003980912,0.0006649465,0.001846098,0.001195875,0.0009537884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006386452,"about_ca_system_score_gemma":0.002117088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00627227,"about_ca_topic_score_gemma":0.01081694,"domain_scores_codex":[0.9945076,0.00242585,0.0004559998,0.001838066,0.0005175406,0.0002550223],"domain_scores_gemma":[0.9922793,0.005086349,0.0006427189,0.0009789987,0.0007035658,0.0003091239],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.003823294,0.0002585694,0.6306614,0.02193604,0.129801,0.001240771,0.0007301604,0.02178357,0.02582461,0.002908254,0.05720731,0.103825],"study_design_scores_gemma":[0.0008975005,0.001022211,0.6877726,0.00595782,0.08853964,0.002454162,0.001317843,0.06154148,0.01191397,0.02078404,0.1172169,0.0005819449],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"empirical","genre_scores_codex":[0.3622798,0.09027357,0.08846414,0.007588579,0.0009903327,0.0005546084,0.4411861,0.004490435,0.004172471],"genre_scores_gemma":[0.6959792,0.01121611,0.05876239,0.002954013,0.0003972585,0.001129698,0.2266959,0.001199178,0.001666243],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9973114,"threshold_uncertainty_score":0.04149491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04881952587545212,"score_gpt":0.2985810259811214,"score_spread":0.2497615001056693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}