{"id":"W4416447621","doi":"10.1021/jacsau.5c00827","title":"Harnessing Bone-Liver Crosstalk: A Dual-Action LYTAC Approach for Bone-Specific Accumulation and Liver-Specific Protein Degradation in Bone Disorders","year":2025,"lang":"en","type":"article","venue":"JACS Au","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Government of Northwest Territories","funders":"Natural Science Foundation of Zhejiang Province; Research Grants Council, University Grants Committee; National Natural Science Foundation of China; First Affiliated Hospital of Zhengzhou University; Hunan Provincial Science and Technology Department; Hong Kong Baptist University","keywords":"Sclerostin; Wnt signaling pathway; Osteogenesis imperfecta; Bone formation; Aptamer; Protein degradation; Mesenchymal stem cell; Mechanism (biology); LRP5","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003285493,0.0002038243,0.0001867745,0.0001862098,0.0002446329,0.0001363438,0.00006275756,0.0002395174,0.000007052411],"category_scores_gemma":[0.00007332696,0.0002149404,0.00007836906,0.0002496707,0.00009564102,0.00004979296,0.00007233763,0.0001184412,0.000002002125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001056263,"about_ca_system_score_gemma":0.00008525237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009175578,"about_ca_topic_score_gemma":0.0001980362,"domain_scores_codex":[0.9986331,0.00007682567,0.0003566555,0.0005314538,0.0001355487,0.00026638],"domain_scores_gemma":[0.9994322,0.00001647338,0.0001567102,0.0002627794,0.00008102132,0.00005081547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005375389,0.0002615412,0.001690651,0.0002105518,0.00002243954,0.000002390596,0.0001945499,0.0002257747,0.8784608,0.001954443,0.001998074,0.1144413],"study_design_scores_gemma":[0.005642595,0.0003513942,0.03922427,0.0002088986,0.00003320471,0.00001983307,0.0008077702,0.0144981,0.6270345,0.0008158772,0.3103769,0.0009866445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9025351,0.003933036,0.09096592,0.0002636631,0.0001784385,0.001445583,0.00001888391,0.00003270651,0.0006266308],"genre_scores_gemma":[0.9912342,0.0006739076,0.00538652,0.00005578495,0.0001661921,0.0003012188,0.0006534683,0.0000258291,0.00150283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3083788,"threshold_uncertainty_score":0.8765014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03604534080034226,"score_gpt":0.2894073011626214,"score_spread":0.2533619603622791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}