{"id":"W4416447989","doi":"10.1093/jimmun/vkaf283.2715","title":"Inhibition of cGAS as a novel treatment for acute myeloid leukemia 9292","year":2025,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Myeloid leukemia; Haematopoiesis; Cytarabine; Leukemia; Myeloid; Immune system; Interferon; Innate immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000629901,0.0002747267,0.0003269213,0.0003566662,0.0001180464,0.0002773347,0.0002743401,0.0002821893,0.003131793],"category_scores_gemma":[0.00005766974,0.00005878115,0.0002914356,0.0002474477,0.0001300358,0.0001680021,0.0001801747,0.0008525593,0.0006606778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001616266,"about_ca_system_score_gemma":0.0001430836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003624646,"about_ca_topic_score_gemma":0.0007132391,"domain_scores_codex":[0.9999571,0.000007132231,0.000004035976,0.000007452563,0.0000140962,0.00001018647],"domain_scores_gemma":[0.9999839,0.000001510673,0.00000390525,0.000001585027,0.000003332249,0.000005690792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003738491,0.001774485,0.001047003,0.001821709,0.0001825754,0.000732174,0.00006753306,0.00085405,0.6062962,0.002479895,0.008047549,0.3729583],"study_design_scores_gemma":[0.003227271,0.01895878,0.01774097,0.0003542532,0.0005687053,0.004242639,0.0001242329,0.004325424,0.6299587,0.001438458,0.3189864,0.00007415636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7403632,0.2160912,0.0100106,0.002528116,0.001497609,0.0006346575,0.001725723,0.0009350474,0.02621395],"genre_scores_gemma":[0.9319537,0.04772821,0.003986003,0.0008524779,0.0002117207,0.0002320649,0.001617726,0.00003239267,0.01338571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003131793,"threshold_uncertainty_score":0.01047695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01375708569777197,"score_gpt":0.283211156703487,"score_spread":0.2694540710057151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}