{"id":"W4416448730","doi":"10.1093/jimmun/vkaf283.1189","title":"First glimpse of immune surveillance during premalignant progression of triple negative breast cancer 3378","year":2025,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Immune system; CD8; Cytotoxic T cell; Cancer; Triple-negative breast cancer; Germinal center; Tumor microenvironment; Tumor progression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003487498,0.0001080905,0.000310728,0.00006334538,0.00006856237,0.000003204739,0.0003351123,0.0001092099,0.00001444548],"category_scores_gemma":[0.00007030452,0.00006960564,0.0001329298,0.0001259808,0.0002381463,0.000004881937,0.00007932918,0.0001468649,1.920551e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000206098,"about_ca_system_score_gemma":0.0001373682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001801908,"about_ca_topic_score_gemma":0.00009794738,"domain_scores_codex":[0.998985,0.000155412,0.0005376659,0.00008402643,0.00008622946,0.0001516724],"domain_scores_gemma":[0.9988469,0.00004055399,0.0005684837,0.0002244687,0.0003038563,0.00001567914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003106197,0.0001316637,0.008339092,0.0000732495,0.0003415929,0.000001588387,0.0002409293,0.0001386919,0.9859446,0.00001788338,0.0000413667,0.001623157],"study_design_scores_gemma":[0.00154412,0.0004000786,0.1338711,0.0002600436,0.00004292,0.00008338143,0.0001576305,0.00001743799,0.8633638,0.00005088469,0.0001452499,0.0000633454],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870517,0.01158884,0.0002203121,0.0004661901,0.000464091,0.0001165664,0.00002375589,0.000001881214,0.00006671742],"genre_scores_gemma":[0.9950135,0.004664195,0.00009253464,0.00001442194,0.00005219696,0.000002549887,0.000001868237,0.000008512625,0.0001502048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.125532,"threshold_uncertainty_score":0.2838435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005995525997557313,"score_gpt":0.2417410897675991,"score_spread":0.2357455637700418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}