{"id":"W4416448915","doi":"10.1093/jimmun/vkaf283.2563","title":"Modeling gene-environment interactions in Parkinson’s Disease: Helicobacter pylori induces CD8 T cell associated motor phenotype in PINK1-/- mice 9116","year":2025,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Université de Montréal; McGill University","funders":"","keywords":"Immune system; Priming (agriculture); FOXP3; CD8; Cytotoxic T cell; T cell; Substantia nigra; PINK1; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001667873,0.0005414145,0.0003061818,0.0003213547,0.0001409915,0.0002907693,0.0002689404,0.0004529817,0.001984761],"category_scores_gemma":[0.00009622547,0.0002648755,0.0003137791,0.0001109837,0.0002584848,0.0001742309,0.0002650882,0.0008439907,0.0003549283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002899081,"about_ca_system_score_gemma":0.000165109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006834314,"about_ca_topic_score_gemma":0.001155272,"domain_scores_codex":[0.999844,0.00003016902,0.00001270199,0.00003974302,0.00003218116,0.00004121257],"domain_scores_gemma":[0.9998591,0.00001676438,0.00004962654,0.000009280946,0.000009590734,0.00005571324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003226264,0.000177772,0.0005880113,0.00002947552,0.00000757983,0.00008316455,0.00002609838,0.000477624,0.9974468,0.0001187996,0.00003885174,0.0006833584],"study_design_scores_gemma":[0.0003172954,0.00413664,0.01667708,0.00003708224,0.0001220869,0.0007278546,0.0001477027,0.01853137,0.9552841,0.0004062422,0.003588978,0.00002361532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963514,0.0001669445,0.002398646,0.00006786688,0.00001404822,0.0000420893,0.0003126942,0.0000830291,0.0005634038],"genre_scores_gemma":[0.9894843,0.0003074467,0.005898714,0.00006792399,0.000007105693,0.0001773429,0.0004266243,0.00005484509,0.003575665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001984761,"threshold_uncertainty_score":0.006639719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0181998665625193,"score_gpt":0.2621008076013771,"score_spread":0.2439009410388578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}