{"id":"W4416449830","doi":"10.1093/jimmun/vkaf283.1437","title":"Fenbendazole promotes TP53 activation and selective cancer cell inhibition with limited impact on normal dermal fibroblasts 3665","year":2025,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Helminth infection and control","field":"Veterinary","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health; Terry Fox Research Institute","keywords":"Viability assay; Trypan blue; Cytotoxicity; Apoptosis; Cytotoxic T cell; Cell culture; Cancer cell; Cell; Prostate cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002060351,0.0001297556,0.0001915874,0.0001401062,0.0001531801,0.00002136724,0.00006795895,0.00008763032,0.0001321671],"category_scores_gemma":[0.00004179233,0.00007459892,0.00004926451,0.0001650413,0.00007475997,0.0002485522,0.00002727131,0.0003871014,0.000005244881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001841933,"about_ca_system_score_gemma":0.0001533105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002455962,"about_ca_topic_score_gemma":0.00003926554,"domain_scores_codex":[0.9991725,0.0002489412,0.0002344642,0.00007885954,0.00008691004,0.0001783028],"domain_scores_gemma":[0.9991609,0.0002324318,0.0002783406,0.00009499002,0.0002068973,0.00002644887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01767899,0.0002541133,0.002053021,0.00002792076,0.0006105242,0.00002038765,0.001537813,0.0004359804,0.9586593,0.00012734,0.0005648267,0.01802976],"study_design_scores_gemma":[0.005363174,0.0116761,0.3542559,0.000443538,0.0001923417,0.001392122,0.0007730798,0.0007364792,0.6240617,0.0001945285,0.0006892949,0.0002217408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958067,0.000256599,0.000834036,0.001161576,0.0001047916,0.0001612263,0.000004047776,0.00001606518,0.001654953],"genre_scores_gemma":[0.9993851,0.00009852671,0.0000191029,0.0002811122,0.000062844,0.000007201723,0.000001401729,0.000009556211,0.0001351118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3522029,"threshold_uncertainty_score":0.3042056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01185805196006111,"score_gpt":0.2829160802468056,"score_spread":0.2710580282867445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}