{"id":"W4416450352","doi":"10.1016/j.psyneuen.2025.107688","title":"Not all saliva samples are equal: The role of cellular heterogeneity in DNA methylation and epigenetic age analyses with biological and psychosocial factors","year":2025,"lang":"en","type":"article","venue":"Psychoneuroendocrinology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canadian Institutes of Health Research; Office of the Director; National Institutes of Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw","keywords":"dNaM; Epigenetics; Saliva; DNA methylation; Immune system; Population","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005745527,0.000413362,0.0007427874,0.0006066996,0.0007396907,0.001777896,0.0005484505,0.0008670044,0.001882926],"category_scores_gemma":[0.01225085,0.0003923562,0.0003471072,0.0007556587,0.0008552717,0.00132507,0.0007614898,0.0007837397,0.000464346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003294805,"about_ca_system_score_gemma":0.0004357817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001957449,"about_ca_topic_score_gemma":0.003209456,"domain_scores_codex":[0.9947897,0.002689922,0.0002758531,0.0009170043,0.001044413,0.000283152],"domain_scores_gemma":[0.996678,0.001582421,0.0004960792,0.0006172899,0.0005085998,0.0001176576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002645452,0.0002825522,0.7206275,0.0007163315,0.0013905,0.0006729026,0.004753611,0.0005634263,0.1236975,0.002725795,0.002915883,0.1390086],"study_design_scores_gemma":[0.00002964324,0.0006950747,0.9219216,0.0001572763,0.0005742704,0.002468988,0.003734868,0.002145453,0.0525331,0.005235726,0.01044439,0.00005955132],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745839,0.007645656,0.01043695,0.001454905,0.0003886778,0.0001160393,0.0008447944,0.000067889,0.004461282],"genre_scores_gemma":[0.9934931,0.0008666023,0.002892044,0.0004829334,0.0001134079,0.00007270027,0.0002198069,0.00003668412,0.001822682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005745527,"threshold_uncertainty_score":0.03038561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06241971644951665,"score_gpt":0.3396529932137394,"score_spread":0.2772332767642228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}