{"id":"W4416452510","doi":"10.1101/2025.11.19.25340633","title":"Elevated plasma neurofilament light chain protein in alcohol use, anorexia nervosa, mania, psychosis and other acute psychiatric disorder presentations","year":2025,"lang":"","type":"preprint","venue":"medRxiv","topic":"Dysphagia Assessment and Management","field":"Health Professions","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Health and Medical Research Council; Medical Research Council; HORIZON EUROPE Framework Programme; Hjärnfonden; University College London; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; Alzheimer's Association; UK Dementia Research Institute; Vetenskapsrådet; Australian Government; Cure Alzheimer's Fund; European Commission; Familjen Erling-Perssons Stiftelse; Stiftelsen för Gamla Tjänarinnor; Alzheimer's Drug Discovery Foundation","keywords":"Psychosis; Glial fibrillary acidic protein; Anorexia; Depression (economics); Alcohol; Lithium (medication); Schizophrenia (object-oriented programming); Alcohol use disorder; Neurofilament","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007313588,0.0001580891,0.0002373117,0.0007927808,0.0002882993,0.0004159092,0.0002112703,0.0001766023,0.002998942],"category_scores_gemma":[0.00262623,0.00011606,0.0002639312,0.0006475099,0.0003422523,0.0001855823,0.0005416452,0.0002830866,0.0002229091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002389314,"about_ca_system_score_gemma":0.0002616736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002250601,"about_ca_topic_score_gemma":0.002632384,"domain_scores_codex":[0.9994629,0.0001987766,0.00006980722,0.0001186916,0.00009316426,0.00005662825],"domain_scores_gemma":[0.999096,0.0003032675,0.0003677232,0.00008176202,0.00006307321,0.00008810467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007487056,0.0000356749,0.9907891,0.00004407464,0.000103842,0.00008004836,0.0001500125,0.00007459691,0.0008052323,0.00003419063,0.0003017112,0.006832911],"study_design_scores_gemma":[0.00002340215,0.000122898,0.9982145,0.00001001618,0.00003458377,0.0001704514,0.000291594,0.0005228979,0.0002485703,0.00009200173,0.000266091,0.000003068632],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981072,0.000180217,0.0004568736,0.000090719,0.00001065993,0.00003179729,0.0006289734,0.00001815663,0.0004753522],"genre_scores_gemma":[0.9988936,0.00003840642,0.0004585023,0.00001855066,0.0000113295,0.00003236179,0.0002992275,0.000002909901,0.000245182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002998942,"threshold_uncertainty_score":0.01003247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04006418183516063,"score_gpt":0.3718633215329654,"score_spread":0.3317991396978047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}