{"id":"W4416452822","doi":"10.33696/immunology.7.235","title":"Mechanisms and Therapeutic Strategies to Overcome Immune Checkpoint Inhibitor Resistance in Melanoma, Head and Neck, and Triple-Negative Breast Cancers","year":2025,"lang":"en","type":"article","venue":"Journal of Cellular Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; York University","keywords":"Immunotherapy; Context (archaeology); Nivolumab; Melanoma; Head and neck squamous-cell carcinoma; Cancer; Acquired resistance; Immune system; Breast cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004701595,0.0003775805,0.0005562069,0.000837084,0.0002353469,0.0008794148,0.0003897541,0.0005841244,0.001361092],"category_scores_gemma":[0.0002746845,0.0001863483,0.0004598465,0.0003191275,0.0003881248,0.0007859104,0.0004772503,0.001640814,0.000444833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005503225,"about_ca_system_score_gemma":0.0005682329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003168466,"about_ca_topic_score_gemma":0.0009503251,"domain_scores_codex":[0.9998693,0.00002848328,0.00001349297,0.00002012081,0.00003641101,0.00003219564],"domain_scores_gemma":[0.9999344,0.00001343732,0.00001948744,0.000004214073,0.00001615916,0.00001221919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003019549,0.0003544326,0.001690468,0.008574264,0.0001978036,0.0009541221,0.0003421696,0.002483675,0.1342771,0.03282347,0.02880431,0.7891962],"study_design_scores_gemma":[0.0001907823,0.001390457,0.004604243,0.002151964,0.0003326068,0.005400953,0.0003240897,0.002403734,0.04465452,0.01759358,0.9208974,0.00005576056],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01460294,0.9668727,0.005417171,0.005456676,0.0008315237,0.00009577192,0.0001011146,0.0001380416,0.006483989],"genre_scores_gemma":[0.1099471,0.8760678,0.004575378,0.003191592,0.001021913,0.0001804499,0.0001956079,0.00001770418,0.004802513],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001361092,"threshold_uncertainty_score":0.004553318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008955093749801885,"score_gpt":0.258282814271548,"score_spread":0.2493277205217461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}