{"id":"W4416454285","doi":"10.1101/2025.11.20.25340644","title":"Effectiveness of the TYPHIBEV® (Vi-CRM197 conjugate) vaccine introduction in Nepal: a test-negative, case-control study","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Salmonella and Campylobacter epidemiology","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"","keywords":"Typhoid fever; Typhoid vaccine; Vaccination; Immunization; Immunogenicity; Odds ratio; Salmonella typhi; Conditional logistic regression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002029536,0.000465801,0.000402071,0.0008559219,0.0006037065,0.0007868164,0.0006637916,0.0008736865,0.0009078039],"category_scores_gemma":[0.004857413,0.0006860968,0.0005610029,0.0005829914,0.0008991243,0.000525878,0.0004108746,0.0004816917,0.0002195823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003603412,"about_ca_system_score_gemma":0.0002796921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003484186,"about_ca_topic_score_gemma":0.002236979,"domain_scores_codex":[0.9981121,0.0008650085,0.0001729161,0.0004533343,0.0002593237,0.0001373744],"domain_scores_gemma":[0.9977429,0.0009434415,0.0006375741,0.0003047516,0.0002212865,0.0001501813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005542818,0.000335948,0.9969388,0.00003202138,0.0001811424,0.0003193656,0.000271458,0.00002062694,0.00041107,0.00002309213,0.00004983977,0.0008624215],"study_design_scores_gemma":[0.0001517106,0.002106966,0.9946103,0.00002514902,0.0002529007,0.001430782,0.0004303004,0.0003114805,0.0003108786,0.0000259823,0.0003324273,0.00001119456],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993387,0.0002014479,0.00008312403,0.000009610852,0.000003442925,0.0000271591,0.00007500519,0.000001157363,0.0002604546],"genre_scores_gemma":[0.9995666,0.0000909431,0.00007123632,0.00002279081,0.000006316424,0.00003842446,0.0001171365,0.000001007826,0.00008559975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003484186,"threshold_uncertainty_score":0.01073337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01614334747129374,"score_gpt":0.2588245656489464,"score_spread":0.2426812181776527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}