{"id":"W4416454377","doi":"10.1007/978-3-031-93616-6_7","title":"Systemic Considerations Relating to Topical Drug Treatment","year":2025,"lang":"en","type":"book-chapter","venue":"","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Drug; Pregnancy; Adverse effect; Drug treatment; Clinical pharmacology; Drug delivery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007242626,0.0003918118,0.0005767203,0.0005669498,0.0006581455,0.001596101,0.0004009563,0.001776136,0.008767763],"category_scores_gemma":[0.00126882,0.0001480566,0.0003977853,0.000315991,0.001079725,0.001075416,0.0007890851,0.003421114,0.003062604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005875363,"about_ca_system_score_gemma":0.000808357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006691505,"about_ca_topic_score_gemma":0.002506112,"domain_scores_codex":[0.9995456,0.0001541342,0.00003002938,0.0000389166,0.0001945988,0.00003665138],"domain_scores_gemma":[0.9995779,0.0002710219,0.0000400183,0.00001808927,0.00006514569,0.00002770147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001026491,0.00009584196,0.0003457717,0.00164434,0.00001919045,0.005865585,0.0005313475,0.000612176,0.01204345,0.06200444,0.1477695,0.7689657],"study_design_scores_gemma":[0.000006506084,0.00008000251,0.0004257371,0.0007937944,0.0000182055,0.0128924,0.0001879108,0.0002574457,0.002349496,0.01051235,0.9724656,0.00001063555],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005380433,0.5708718,0.02718804,0.03742824,0.009926125,0.000101603,0.00007673124,0.00024014,0.3487869],"genre_scores_gemma":[0.0838826,0.4710942,0.02500631,0.03321308,0.01869301,0.0002269071,0.0001207963,0.0002513232,0.3675118],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008767763,"threshold_uncertainty_score":0.02933109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1259225427096501,"score_gpt":0.4296541851423569,"score_spread":0.3037316424327068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}