{"id":"W4416463379","doi":"10.21956/gatesopenres.14371.r29656","title":"Referee report. For: Whole blood genome-wide transcriptome profiling and metagenomics next-generation sequencing in young infants with suspected sepsis in low-and middle-income countries: A study protocol [version 1; peer review: 2 approved with reservations]","year":2020,"lang":"en","type":"article","venue":"Faculty of 1000 Research Ltd","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Grand Challenges Canada; Michael Smith Health Research BC; BC Children's Hospital; Children's Hospital Foundation; Bill and Melinda Gates Foundation","keywords":"Sepsis; Whole blood; Metagenomics; Transcriptome; Protocol (science); Profiling (computer programming)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001748496,0.0001939389,0.0003496238,0.000144478,0.0001403522,0.00008387135,0.0001897669,0.00009418226,0.00000410516],"category_scores_gemma":[0.0008785983,0.0001537781,0.00003668839,0.0003849456,0.0001161213,0.00003534122,0.0001152371,0.0002092073,3.961802e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000844255,"about_ca_system_score_gemma":0.0005019005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003349012,"about_ca_topic_score_gemma":0.002696011,"domain_scores_codex":[0.9977298,0.0001996252,0.0005093822,0.0006202387,0.0006103712,0.000330561],"domain_scores_gemma":[0.9978116,0.0000386169,0.0001600427,0.0003170117,0.001535159,0.0001375884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003522386,0.0003557153,0.294726,0.006149057,0.000326205,0.0001981584,0.003246553,0.0004100939,0.6906919,0.00000923117,0.0003361405,0.00002851187],"study_design_scores_gemma":[0.06276739,0.02751271,0.424815,0.01448687,0.001074257,0.000357587,0.04285543,0.01151787,0.3446119,0.00009654389,0.06551559,0.004388823],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9693643,0.0004212881,0.0000644339,0.00229054,0.000004012625,0.02756133,0.0002494123,0.000007040534,0.00003768546],"genre_scores_gemma":[0.9852231,0.0002121925,0.001787574,0.00007848749,0.00004351251,0.01055662,0.001452495,0.0000377675,0.0006082588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.34608,"threshold_uncertainty_score":0.6270888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07482609292406453,"score_gpt":0.3405099523411692,"score_spread":0.2656838594171047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}