{"id":"W4416470123","doi":"10.21956/gatesopenres.16671.r36085","title":"Referee report. For: Taking stock: Is gene drive research delivering on its principles? [version 1; peer review: 1 approved, 3 approved with reservations]","year":2024,"lang":"en","type":"article","venue":"Faculty of 1000 Research Ltd","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"McMaster University; World Health Organization; Bill and Melinda Gates Foundation","keywords":"Action (physics); The Internet; Control (management)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.008214124,0.0009522843,0.001612356,0.003075054,0.004270568,0.005929048,0.003117911,0.009331315,0.5439649],"category_scores_gemma":[0.08617972,0.000589561,0.001281439,0.002889481,0.00105872,0.003367313,0.003138175,0.006100875,0.4297636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004589827,"about_ca_system_score_gemma":0.007083558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02063866,"about_ca_topic_score_gemma":0.03419325,"domain_scores_codex":[0.9933438,0.0007425032,0.0004778939,0.0007750384,0.004181935,0.0004787464],"domain_scores_gemma":[0.9097044,0.01121141,0.001420389,0.003855944,0.07008828,0.003719584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000005430225,0.000004357391,0.00001662392,0.0000224481,0.000001139152,0.00002110661,0.00001058632,0.000004231129,0.0000494235,0.0002825551,0.997077,0.002505158],"study_design_scores_gemma":[0.0000142636,0.00001140421,0.0004466783,0.00009510262,0.000008437457,0.00008647243,0.00010951,0.00006612989,0.0002288473,0.001039157,0.9978673,0.00002659148],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0005717283,0.003738292,0.004549796,0.4372089,0.3462368,0.001203225,0.01988547,0.006074178,0.1805316],"genre_scores_gemma":[0.003967629,0.002037519,0.00217395,0.07086115,0.02448909,0.0005919343,0.005199421,0.001726556,0.8889527],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.5439649,"threshold_uncertainty_score":0.6504787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1274379450052959,"score_gpt":0.4444978972363278,"score_spread":0.3170599522310318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}