{"id":"W4416488722","doi":"10.1021/acschemneuro.5c00874","title":"Engineered Commensals as Next-Generation Drug Delivery Agents for Nose-to-Brain Therapeutics in Neurological Disorders","year":2025,"lang":"en","type":"review","venue":"ACS Chemical Neuroscience","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Paediatric Society","funders":"","keywords":"Nasal administration; Drug delivery; Targeted drug delivery; Central nervous system; Immune system; Drug; Biocompatible material; Genetically engineered","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003587253,0.0007849453,0.0008206688,0.001657394,0.0002058921,0.0007475266,0.0006068078,0.0008935168,0.002759534],"category_scores_gemma":[0.0002878741,0.0002866939,0.0003928292,0.001408995,0.0003091378,0.001087097,0.0005562344,0.00145211,0.001983127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004565519,"about_ca_system_score_gemma":0.0005158999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007332336,"about_ca_topic_score_gemma":0.001452969,"domain_scores_codex":[0.9998865,0.00001711377,0.00001061184,0.00001893491,0.0000511303,0.0000157353],"domain_scores_gemma":[0.9999212,0.00002802037,0.00001547706,0.000003385364,0.00002099842,0.00001088106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006837954,0.0001526273,0.0001125447,0.01333436,0.00007126775,0.0002536734,0.0000659919,0.0008062129,0.0151049,0.01054247,0.01813916,0.9413485],"study_design_scores_gemma":[0.00001643063,0.000146678,0.000486215,0.001532868,0.00006785955,0.0006456077,0.00003450295,0.000208483,0.003308611,0.001716357,0.9918185,0.00001785676],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005386532,0.9963059,0.0004869397,0.0001620605,0.0002004144,0.00001355646,0.00002761472,0.00001755009,0.002247368],"genre_scores_gemma":[0.002106349,0.9954913,0.0005583477,0.0001557728,0.00006320978,0.00001750312,0.00004059698,0.00000305746,0.001563938],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002759534,"threshold_uncertainty_score":0.009231627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2669730323409753,"score_gpt":0.4743475078884105,"score_spread":0.2073744755474352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}