{"id":"W4416508536","doi":"10.1172/jci.insight.198074","title":"Spatial transcriptomics reveals immune-stromal crosstalk within the synovium of patients with juvenile idiopathic arthritis","year":2025,"lang":"en","type":"article","venue":"JCI Insight","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Artificial Intelligence in Medicine (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Japan Society for the Promotion of Science; Mochida Memorial Foundation for Medical and Pharmaceutical Research; Uehara Memorial Foundation","keywords":"Colocalization; Synovitis; Transcriptome; Crosstalk; Arthritis; Rheumatoid arthritis; Immune system; Stromal cell; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001711444,0.0001685978,0.0002608695,0.0006810919,0.0001801808,0.0004605128,0.0001089562,0.000205654,0.0009061719],"category_scores_gemma":[0.0003221222,0.0001463822,0.0002535588,0.0005530181,0.0002061383,0.000153438,0.0002873306,0.000183082,0.0002206617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001822773,"about_ca_system_score_gemma":0.0002308886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002304642,"about_ca_topic_score_gemma":0.004882507,"domain_scores_codex":[0.9998446,0.00002632794,0.0000118311,0.00005142734,0.00003283055,0.00003303312],"domain_scores_gemma":[0.9998705,0.00003706375,0.00004689696,0.00001078041,0.00002012906,0.00001463415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008576873,0.00004474981,0.3066477,0.0002542311,0.0001937634,0.0008466385,0.0006125246,0.005284385,0.6448856,0.0004241588,0.0006759273,0.03927258],"study_design_scores_gemma":[0.00003149662,0.0001995108,0.916213,0.00004116306,0.0002004623,0.001982376,0.00148533,0.02646225,0.04958203,0.0008914685,0.002877317,0.00003360971],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921062,0.0007375312,0.005144662,0.00008007928,0.000004891366,0.000008173627,0.001331753,0.0001084733,0.0004783734],"genre_scores_gemma":[0.9950782,0.0002597239,0.003639294,0.00003300476,0.000006887181,0.00001169111,0.0007184486,0.00001927267,0.0002334611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002304642,"threshold_uncertainty_score":0.004582405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008370504884521799,"score_gpt":0.2422844020384925,"score_spread":0.2339138971539707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}