{"id":"W4416509641","doi":"10.1002/slct.202503721","title":"O‐Silyl Codeine Analogues as Ligands for Opioid Receptors","year":2025,"lang":"en","type":"article","venue":"ChemistrySelect","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Purdue Pharma (Canada); Ontario Tech University","funders":"Natural Sciences and Engineering Research Council of Canada; Purdue Pharma; Purdue University","keywords":"Codeine; Opioid; Opioid receptor; Receptor; Ether; Prodrug; Lead compound; Naltrindole","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007570669,0.0002939202,0.0001696341,0.0001328133,0.00008059411,0.00012692,0.0002490503,0.0002236728,0.001862505],"category_scores_gemma":[0.000105449,0.0000798548,0.0001463166,0.0001075016,0.0001303474,0.0001497911,0.0001590635,0.0003728747,0.0004678828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001812345,"about_ca_system_score_gemma":0.0001644484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003781071,"about_ca_topic_score_gemma":0.0007740204,"domain_scores_codex":[0.9999368,0.00001342134,0.000004940224,0.00001166698,0.00001648878,0.0000168076],"domain_scores_gemma":[0.9999303,0.00001276918,0.0000238177,0.000005880346,0.00001139314,0.00001578111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001459906,0.00003237176,0.00008673697,0.0001297767,0.000006745545,0.0001256755,0.00001742664,0.0002422466,0.9951922,0.000318149,0.0000951,0.00360751],"study_design_scores_gemma":[0.00004190575,0.0008964433,0.0007878169,0.00001085428,0.0000178941,0.0002067208,0.00001232236,0.0007532323,0.9889787,0.00005340866,0.008230782,0.000009957181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768088,0.004306088,0.008424941,0.0001609381,0.00008990307,0.0001242056,0.0005028286,0.0001032473,0.009479073],"genre_scores_gemma":[0.9856506,0.0022438,0.005773198,0.0001491512,0.00002472263,0.00007924819,0.0003844974,0.00002365315,0.005671183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001862505,"threshold_uncertainty_score":0.006230652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01817328813397251,"score_gpt":0.2952356682975796,"score_spread":0.2770623801636071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}