{"id":"W4416509641","doi":"10.1002/slct.202503721","title":"O‐Silyl Codeine Analogues as Ligands for Opioid Receptors","year":2025,"lang":"en","type":"article","venue":"ChemistrySelect","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Purdue Pharma (Canada); Ontario Tech University","funders":"Natural Sciences and Engineering Research Council of Canada; Purdue Pharma; Purdue University","keywords":"Codeine; Opioid; Opioid receptor; Receptor; Ether; Prodrug; Lead compound; Naltrindole","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004198245,0.0001513206,0.0001903003,0.00003205844,0.0001468508,0.00003615595,0.0002945003,0.00006785991,0.00006836813],"category_scores_gemma":[0.0006971254,0.0001381007,0.00008263053,0.0003061707,0.0001005296,0.00004322873,0.00006453566,0.0001282421,0.00004028295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002440851,"about_ca_system_score_gemma":0.00007981804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000509233,"about_ca_topic_score_gemma":7.083591e-7,"domain_scores_codex":[0.9989882,0.000006997406,0.0001682089,0.0004566215,0.00007314148,0.0003067944],"domain_scores_gemma":[0.9994367,0.000202006,0.00005386986,0.0002026723,0.00004477614,0.00005993158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007595642,0.0000391955,0.00004413345,0.00006165571,0.000004879623,0.000003058077,0.00001186419,0.000003127157,0.9764388,0.0009776591,0.02128831,0.001051372],"study_design_scores_gemma":[0.0002882249,0.0001497216,0.00004003596,0.00002323016,0.000009953495,0.000004400511,0.000008434339,0.00006101371,0.9375143,0.003409911,0.05836542,0.0001253466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805483,0.00007211458,0.00003538756,0.0002400199,0.0002245645,0.0001591059,0.00001767225,0.0001257965,0.01857701],"genre_scores_gemma":[0.9859869,0.00009002217,0.00004082283,0.001939256,0.0001537494,0.000040116,0.00001556101,0.00001618426,0.01171735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03892449,"threshold_uncertainty_score":0.5631583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01817328813397251,"score_gpt":0.2952356682975796,"score_spread":0.2770623801636071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}