{"id":"W4416523153","doi":"10.1016/j.medj.2025.100928","title":"IsomiR utility in amyotrophic lateral sclerosis prognostication","year":2025,"lang":"en","type":"article","venue":"Med","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Robert Packard Center for ALS Research, Johns Hopkins University; Israel Science Foundation; National Institute of Neurological Disorders and Stroke; Bundesministerium für Bildung und Forschung; E-Rare; Rare Diseases Clinical Research Network; Thomas Jefferson University; Minerva Foundation; Association Française contre les Myopathies; French Muscular Dystrophy Association; United States - Israel Binational Science Foundation; Muscular Dystrophy Association; National Center for Advancing Translational Sciences; ALS Association; Target ALS; ALS Society of Canada; McGill University; U.S. Department of Defense","keywords":"Amyotrophic lateral sclerosis; Disease; MEDLINE; Foundation (evidence); Multiple sclerosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004519185,0.001139406,0.001334309,0.002190598,0.0006820611,0.00320241,0.0005899969,0.00117601,0.003814137],"category_scores_gemma":[0.008302891,0.00035213,0.0006868565,0.001331198,0.0006581991,0.001077345,0.001302368,0.001286433,0.001959857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004706438,"about_ca_system_score_gemma":0.0004931124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004916891,"about_ca_topic_score_gemma":0.000696839,"domain_scores_codex":[0.998268,0.0007079235,0.0001587245,0.0003482719,0.0003763671,0.000140642],"domain_scores_gemma":[0.9969548,0.001346321,0.0005276113,0.0002845254,0.0006890313,0.0001976628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01177275,0.0005335656,0.5602944,0.001247192,0.002346182,0.0007843386,0.0006459698,0.005278891,0.06110633,0.004907589,0.008691135,0.3423917],"study_design_scores_gemma":[0.0007722432,0.004868104,0.6139898,0.002153155,0.00643472,0.006416669,0.002159792,0.08458877,0.1172396,0.06910928,0.09176271,0.0005052042],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8794026,0.04673903,0.03896529,0.004583754,0.001871335,0.0001475638,0.004888839,0.001106856,0.02229471],"genre_scores_gemma":[0.975512,0.003155529,0.01405491,0.001000517,0.0006094725,0.00009089605,0.001932017,0.0001212294,0.003523356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004519185,"threshold_uncertainty_score":0.02389997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04322506694736663,"score_gpt":0.320959468944043,"score_spread":0.2777344019966764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}