{"id":"W4416523153","doi":"10.1016/j.medj.2025.100928","title":"IsomiR utility in amyotrophic lateral sclerosis prognostication","year":2025,"lang":"en","type":"article","venue":"Med","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Robert Packard Center for ALS Research, Johns Hopkins University; Israel Science Foundation; National Institute of Neurological Disorders and Stroke; Bundesministerium für Bildung und Forschung; E-Rare; Rare Diseases Clinical Research Network; Thomas Jefferson University; Minerva Foundation; Association Française contre les Myopathies; French Muscular Dystrophy Association; United States - Israel Binational Science Foundation; Muscular Dystrophy Association; National Center for Advancing Translational Sciences; ALS Association; Target ALS; ALS Society of Canada; McGill University; U.S. Department of Defense","keywords":"Amyotrophic lateral sclerosis; Disease; MEDLINE; Foundation (evidence); Multiple sclerosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003379528,0.0001242578,0.0002661416,0.0002223783,0.00005292905,0.00002657565,0.0001328663,0.000103429,0.0002859744],"category_scores_gemma":[0.000315175,0.0001019024,0.00006296602,0.0006623739,0.0001131017,0.00008195492,0.00009046136,0.0003137996,0.0001158879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001888304,"about_ca_system_score_gemma":0.0001405584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002655599,"about_ca_topic_score_gemma":0.00005438915,"domain_scores_codex":[0.9985667,0.0001057125,0.0003104611,0.0003396828,0.0003068736,0.0003705206],"domain_scores_gemma":[0.9992896,0.00007554092,0.00003116572,0.0003864408,0.0001104244,0.000106866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001008914,0.0006765776,0.8437261,0.0002197908,0.00007015777,0.00003717383,0.0003181702,0.000003702069,0.1010792,0.0006451885,0.006985005,0.04523005],"study_design_scores_gemma":[0.001599151,0.00007376515,0.9908061,0.0002802671,0.00001742886,0.000001681422,0.00001159869,0.001966757,0.002149655,0.0004281436,0.002588417,0.00007700775],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755465,0.0001339629,0.00008849476,0.01985059,0.0001030431,0.0007811923,0.000003152129,0.0000812321,0.003411856],"genre_scores_gemma":[0.9961939,0.0001051092,0.0003847933,0.001292067,0.00003494205,0.000145855,0.00002477208,0.00001242435,0.001806134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.14708,"threshold_uncertainty_score":0.4155459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04322506694736663,"score_gpt":0.320959468944043,"score_spread":0.2777344019966764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}