{"id":"W4416526623","doi":"10.1038/s41467-025-66522-0","title":"Cryo-electron microscopy reveals sequential binding and activation of Ryanodine Receptors by statin triplets","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"RYR1; Ryanodine receptor; Statin; Atorvastatin; Protein subunit; Binding site; Transmembrane protein; Transmembrane domain","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000114949,0.0002264614,0.0001370511,0.000189657,0.0004054632,0.0002865531,0.0003311656,0.0006530085,0.002567317],"category_scores_gemma":[0.0001809577,0.0002895689,0.0002359272,0.0001189411,0.000317095,0.0004674964,0.0003472435,0.00126938,0.0006568431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002979729,"about_ca_system_score_gemma":0.0001764547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001705289,"about_ca_topic_score_gemma":0.001553462,"domain_scores_codex":[0.9999368,0.000005188431,0.000003481983,0.00001313642,0.00002004922,0.00002136],"domain_scores_gemma":[0.9998918,0.00002993459,0.00001760778,0.00001533729,0.00002507285,0.00002029089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003064436,0.00007480488,0.002547109,0.0002236075,0.00005680895,0.002035699,0.0002046044,0.001700794,0.9859324,0.001336762,0.002091408,0.003489694],"study_design_scores_gemma":[0.0001393199,0.0005464908,0.1190675,0.0002419999,0.0001803772,0.00941499,0.001171817,0.03735243,0.7902797,0.002162546,0.03931782,0.0001250364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714097,0.00435281,0.01148463,0.001571869,0.0002164703,0.0000285744,0.0007927408,0.0002704922,0.009872699],"genre_scores_gemma":[0.9822313,0.002275628,0.00843302,0.0004778257,0.00004944011,0.00003619438,0.000907205,0.00009554619,0.005493775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002567317,"threshold_uncertainty_score":0.008588552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01446012708568414,"score_gpt":0.3427905159312079,"score_spread":0.3283303888455238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}