{"id":"W4416528701","doi":"10.1021/acscatal.5c05739","title":"Facile Synthesis of β,β-(Radio)difluoroamines via Amino(radio)fluorination of α-Fluoroalkenes","year":2025,"lang":"en","type":"article","venue":"ACS Catalysis","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada Foundation for Innovation; Azrieli Foundation; National Natural Science Foundation of China; Canada Research Chairs","keywords":"Bespoke; Alkene; Nucleophile; Electrophile; Catalysis; Construct (python library)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005646644,0.0003262053,0.0007475336,0.0003304271,0.0001222331,0.000009700662,0.0006883717,0.0004353541,0.0008722603],"category_scores_gemma":[0.0007996176,0.0003400441,0.0002776418,0.001050133,0.000409241,0.0001545469,0.00021676,0.0003651643,0.00004230806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001399137,"about_ca_system_score_gemma":0.0001336818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001739157,"about_ca_topic_score_gemma":0.00001765692,"domain_scores_codex":[0.9978181,0.0001820286,0.0008808284,0.0004632608,0.0002853415,0.0003704391],"domain_scores_gemma":[0.9972574,0.001210613,0.0004062713,0.0006992695,0.0003159443,0.0001104758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001158429,0.0005296205,0.02684752,0.000588413,0.00117079,0.00001009795,0.0003083951,0.0001636157,0.8799533,0.0004105994,0.003592139,0.08630963],"study_design_scores_gemma":[0.0005720027,0.00003293769,0.004726955,0.00003993772,0.001091183,0.00001197445,0.0001666933,0.0005850065,0.9830148,0.0002171912,0.009293736,0.0002476181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990436,0.002265781,0.0004095177,0.0006641664,0.0006486503,0.0002607557,0.0002040519,0.0001046023,0.005006453],"genre_scores_gemma":[0.9948459,0.0003454044,0.0004398138,0.00008027528,0.0001208342,0.00007769234,0.0001267637,0.00002790534,0.003935463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1030614,"threshold_uncertainty_score":0.9999052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03522903358972797,"score_gpt":0.3650064962344011,"score_spread":0.3297774626446731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}