{"id":"W4416533130","doi":"10.1016/j.nexres.2025.101031","title":"A theoretical framework for the design and optimization of a novel point-of-care lactate biosensor","year":2025,"lang":"en","type":"article","venue":"Next research.","topic":"Electrochemical sensors and biosensors","field":"Engineering","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Mitacs","keywords":"Biosensor; Glucose oxidase; Amperometry; Ferricyanide; Modular design; Analyte","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003394748,0.00007539388,0.0001379473,0.00008216982,0.00005943852,0.00002500668,0.0001302172,0.0001073359,0.00002098351],"category_scores_gemma":[0.0006766591,0.00004980224,0.00004510234,0.0003353657,0.0003074218,0.00002685319,0.00003548536,0.0002274917,4.025052e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002203841,"about_ca_system_score_gemma":0.00002027996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004276858,"about_ca_topic_score_gemma":6.013953e-7,"domain_scores_codex":[0.9992886,0.00004589537,0.0001534266,0.0001163648,0.0001561529,0.0002396213],"domain_scores_gemma":[0.9971995,0.002394124,0.00001458299,0.0001593446,0.0001962934,0.00003618248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0005210474,0.00006761504,0.00001501528,0.0006735344,0.0001173271,7.681676e-7,0.0006477918,0.05625578,0.3803392,0.5509342,0.0004854799,0.009942235],"study_design_scores_gemma":[0.0003727252,0.0001625772,0.00002483673,0.0001686266,0.00002031408,9.896916e-7,0.0004171365,0.5786377,0.4070346,0.01290228,0.0001841719,0.00007395787],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.06549324,0.002180732,0.9290673,0.001157184,0.00005213949,0.0009722573,0.00001716322,0.00005533509,0.001004631],"genre_scores_gemma":[0.88717,0.0004179199,0.1123136,0.00001904339,0.00002217573,0.00002241659,0.000002063831,0.00001310706,0.000019721],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.8216767,"threshold_uncertainty_score":0.2030877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03788627362077083,"score_gpt":0.3215809323143116,"score_spread":0.2836946586935408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}