{"id":"W4416537669","doi":"10.1002/dad2.70217","title":"Plasma lipid metabolites as biomarkers of early white matter degeneration in Alzheimer's disease","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"White matter; Disease; Lipid accumulation; Metabolite; Magnetic resonance imaging; Biomarker","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005987535,0.0005476442,0.0004128786,0.0008974916,0.0002772477,0.0007536975,0.0002184734,0.0003924634,0.001153689],"category_scores_gemma":[0.001007474,0.0001551679,0.0001935373,0.0008641869,0.0001699053,0.0003400135,0.0003361422,0.0002872816,0.0002091872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002272552,"about_ca_system_score_gemma":0.0002807616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001468983,"about_ca_topic_score_gemma":0.001756954,"domain_scores_codex":[0.9998283,0.00004682727,0.00002782307,0.00004569743,0.00003357057,0.00001772402],"domain_scores_gemma":[0.999508,0.00008146565,0.000270654,0.00002579437,0.00007464724,0.00003940105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002292151,0.0001835921,0.9540472,0.0003061823,0.0004940743,0.0003409694,0.0001858555,0.000321295,0.01224074,0.0001543436,0.0004289363,0.02900472],"study_design_scores_gemma":[0.00003791269,0.000475546,0.9930178,0.00005638254,0.000267137,0.0007297741,0.0001038003,0.0005422923,0.003039595,0.000576539,0.001139597,0.00001362647],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879886,0.008413893,0.0008099902,0.0001207509,0.00002077555,0.00003424133,0.001631056,0.00002851804,0.0009521893],"genre_scores_gemma":[0.9960507,0.001456795,0.001331133,0.00005640457,0.0000228176,0.00002958869,0.0006063091,0.000004341095,0.0004419954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001468983,"threshold_uncertainty_score":0.00385946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0265600707172568,"score_gpt":0.3417149870817052,"score_spread":0.3151549163644484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}