{"id":"W4416538899","doi":"10.2337/dc25-1508","title":"The Role of Adaptive and Innovative Trial Designs in Diabetes Research: A Scoping Review","year":2025,"lang":"en","type":"article","venue":"Diabetes Care","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIHR Leicester Biomedical Research Centre; National Health and Medical Research Council; Medical Research Council; Diabetes Victoria; MTPConnect; Servier; Nestlé Health Science; Deakin University; Diabetes Australia; British Heart Foundation; Novo Nordisk; Daiichi-Sankyo; National Institute for Health and Care Research; Diabetes Canada; Sanofi; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company","keywords":"Incentive; Diabetes mellitus; Protocol (science); Research design; Clinical trial; MEDLINE","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.3788362,0.003059567,0.01210594,0.0297038,0.00317662,0.0200742,0.007364682,0.01152366,0.005980018],"category_scores_gemma":[0.7151607,0.003291981,0.013203,0.03089506,0.008235319,0.01992968,0.007670893,0.007897139,0.001198075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.02047716,"about_ca_system_score_gemma":0.06690401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007585716,"about_ca_topic_score_gemma":0.01103666,"domain_scores_codex":[0.5251951,0.3271504,0.1028317,0.009485374,0.03302723,0.002310128],"domain_scores_gemma":[0.1470242,0.7779312,0.03411702,0.01291384,0.02695429,0.001059286],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0003422055,0.00005391933,0.00103229,0.7793919,0.004645226,0.0001011868,0.001978326,0.0006683019,0.0001160195,0.009487722,0.005331767,0.196851],"study_design_scores_gemma":[0.0001306909,0.00008535006,0.0004226668,0.9752074,0.004317169,0.00006322603,0.0003621284,0.0002254947,0.00008197976,0.003383494,0.01568927,0.00003120066],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004684031,0.9867781,0.003361356,0.003971281,0.001263533,0.002847092,0.0002271212,0.00003591647,0.001047222],"genre_scores_gemma":[0.01467207,0.9474152,0.01746327,0.004280605,0.001033388,0.01451427,0.0003128383,0.00005862952,0.0002498747],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6211638,"threshold_uncertainty_score":0.7660056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6309787262186826,"score_gpt":0.6005206558920146,"score_spread":0.03045807032666792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}