{"id":"W4416548576","doi":"10.1021/acssensors.5c01883","title":"Genetically Encoded Sensors for Monitoring Intracellular Redox Health of the Pathogenic Fungus <i>Cryptococcus neoformans</i>","year":2025,"lang":"en","type":"article","venue":"ACS Sensors","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Canadian Institute for Advanced Research; Burroughs Wellcome Fund","keywords":"Intracellular; Virulence; Redox; Context (archaeology); Mutant; Oxidative stress; Fungus; Genetic screen; Intracellular parasite","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002565839,0.0004295097,0.0002034405,0.0002398938,0.0001091065,0.0002568421,0.0003391333,0.000339236,0.0003862057],"category_scores_gemma":[0.0002829487,0.0001255777,0.0002116154,0.0002057499,0.0002331452,0.000195167,0.0002565293,0.0005047683,0.0001137645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005518752,"about_ca_system_score_gemma":0.000278981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001566462,"about_ca_topic_score_gemma":0.002422135,"domain_scores_codex":[0.9997836,0.00002903897,0.00001435147,0.00004886278,0.00008800914,0.00003629695],"domain_scores_gemma":[0.9998386,0.00002413672,0.00007036822,0.0000147531,0.00002996405,0.00002228508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001621438,0.000008933637,0.000108744,0.00001490629,0.000001188129,0.000007863707,0.000003563471,0.00007527918,0.9985702,0.00005276532,0.00001506435,0.001125285],"study_design_scores_gemma":[0.000002116182,0.00006099645,0.000854886,0.000002420543,0.000004216211,0.00004861466,0.000006225726,0.0005137856,0.9979687,0.00002027589,0.0005141721,0.00000358693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9505684,0.001160367,0.04437666,0.0003445366,0.00006339412,0.0001650427,0.0008399675,0.0003480166,0.002133777],"genre_scores_gemma":[0.947951,0.0007133637,0.04924433,0.000118042,0.00001100612,0.00005235941,0.0005042457,0.00003070756,0.001374998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001566462,"threshold_uncertainty_score":0.00400418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01528714855859889,"score_gpt":0.2868549232653062,"score_spread":0.2715677747067073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}