{"id":"W4416548985","doi":"10.1016/j.jare.2025.11.047","title":"Exploring the role of β2-microglobulin in the relationship between physical activity and DNAm-predicted PhenoAge: Evidence from a population-based and mice single-cell RNA-sequencing study","year":2025,"lang":"en","type":"article","venue":"Journal of Advanced Research","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health","funders":"Tsinghua Initiative Scientific Research Program; Tsinghua University","keywords":"Physical activity; Longevity; Inflammation; Psychological intervention; Healthy aging","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001279079,0.00009282042,0.0001754455,0.0001101572,0.0001664293,0.00004558228,0.0002779101,0.00004442811,3.980472e-7],"category_scores_gemma":[0.001201098,0.00006376846,0.00003946632,0.0002466856,0.0001148389,0.00002896843,0.000112713,0.0004961898,1.001996e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004767149,"about_ca_system_score_gemma":0.0001328589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002947105,"about_ca_topic_score_gemma":0.0001217795,"domain_scores_codex":[0.9984232,0.0006305679,0.0002432191,0.0001879455,0.0003481829,0.0001669255],"domain_scores_gemma":[0.9980087,0.001372657,0.0001477932,0.0002371717,0.0001936998,0.00003997875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00012933,0.0001349333,0.3419924,0.00002224175,0.0000185547,0.000001795454,0.002224609,0.001453494,0.649996,0.000003233007,0.000002813848,0.004020571],"study_design_scores_gemma":[0.0005987121,0.0004159363,0.7841766,0.0001297811,0.00003428944,0.000001329297,0.004214621,0.0003811771,0.20922,0.0007543315,0.00001350013,0.00005963516],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974802,0.001118283,0.0007444089,0.0003359032,0.00003107997,0.0002655065,0.000006532309,0.00000162282,0.00001643785],"genre_scores_gemma":[0.9991388,0.00009465504,0.0006103991,0.00001268573,0.0001158499,0.00000799409,0.000002644424,0.000007948108,0.000008993275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4421843,"threshold_uncertainty_score":0.2600403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1330217437989321,"score_gpt":0.36244290090879,"score_spread":0.2294211571098579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}