{"id":"W4416551047","doi":"10.1101/2025.11.21.689741","title":"Genetic variation of human G6PD impacts Red Blood Cell transfusion efficacy","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neonatal Health and Biochemistry","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of British Columbia","funders":"","keywords":"Red blood cell; Genetic variation; Variation (astronomy); Blood transfusion; Blood cell; Red Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003426121,0.0004619127,0.0007395601,0.0002610617,0.0001166359,0.00002859145,0.0002974581,0.00081425,0.00007424706],"category_scores_gemma":[0.000129702,0.0004759576,0.0002276079,0.0004493574,0.00007310226,0.00003337066,0.0001727752,0.0008058905,0.000007597603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001711582,"about_ca_system_score_gemma":0.001408173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001824759,"about_ca_topic_score_gemma":0.000001691795,"domain_scores_codex":[0.9973552,0.00007555893,0.0008167045,0.0008177161,0.0004549734,0.0004798524],"domain_scores_gemma":[0.9973561,0.00005348507,0.000449017,0.001212285,0.0004911927,0.0004379834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001633397,0.0006736245,0.004629485,0.007627785,0.0000979352,0.00005449196,0.00001528164,0.000004706077,0.9866305,0.00001616797,0.00008265299,0.000004040554],"study_design_scores_gemma":[0.001970458,0.0001859481,0.3100787,0.001377677,0.000462025,3.280539e-8,8.726129e-7,0.00002808507,0.6854623,8.33361e-7,0.0001593848,0.0002736548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995634,0.001904728,0.0001388133,0.0001792931,0.0004416931,0.001178756,0.0002482943,0.0001882112,0.00008620152],"genre_scores_gemma":[0.9955209,0.0006947647,0.003066551,0.0001535147,0.0004216229,0.000053673,0.000002504738,0.00005759593,0.00002881242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3054492,"threshold_uncertainty_score":0.9997692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01107220871790854,"score_gpt":0.2488056235799233,"score_spread":0.2377334148620147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}