{"id":"W4416563987","doi":"10.1101/2025.11.23.690019","title":"LsrL modulates Lsr2-induced chromatin structure to tune biosynthetic gene cluster regulation in <i>Streptomyces venezuelae</i>","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; National Institute for Health and Care Research","keywords":"Chromatin; Transcriptional regulation; Gene; Chromosome; Regulation of gene expression; Gene cluster; Function (biology); ChIA-PET","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001287716,0.0001640321,0.0001629751,0.0001817169,0.0001600475,0.0003696048,0.0001236556,0.0001258135,0.001154717],"category_scores_gemma":[0.0001231846,0.0001217958,0.0001117373,0.0001435195,0.0002164887,0.00008232474,0.00024719,0.0002508025,0.0002185232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004352918,"about_ca_system_score_gemma":0.0001475177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003053254,"about_ca_topic_score_gemma":0.004601268,"domain_scores_codex":[0.9999058,0.0000139402,0.000004035819,0.00004326985,0.00001498465,0.00001787764],"domain_scores_gemma":[0.9999372,0.00001128339,0.00002442907,0.000007617962,0.000005830031,0.00001364312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005296454,0.000005124155,0.0009379755,0.000009227419,0.00000151188,0.000009556726,0.00001066363,0.000067008,0.9983975,0.00002581812,0.00001356997,0.0004690012],"study_design_scores_gemma":[0.00002570181,0.0001357882,0.1315529,0.00001054399,0.00001314339,0.0001519039,0.0001679625,0.004822636,0.8602642,0.0001067347,0.002733003,0.00001544621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976588,0.0002224258,0.00111082,0.00003160119,0.000005096399,0.000004349012,0.0002689779,0.00006507926,0.0006326913],"genre_scores_gemma":[0.9986266,0.00004519473,0.0005347056,0.00001468948,0.000001634239,0.000003193158,0.0002711593,0.00001486153,0.0004879143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003053254,"threshold_uncertainty_score":0.006070971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009667572119001646,"score_gpt":0.2238931718958786,"score_spread":0.2142255997768769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}