{"id":"W4416574801","doi":"10.1128/spectrum.02928-25","title":"The CpxR response regulator mediates the virulence of <i>Klebsiella pneumoniae</i> by regulating the expression of virulence-associated genes","year":2025,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Natural Science Foundation of China; Natural Science Foundation of Guangxi Zhuang Autonomous Region","keywords":"Virulence; Gene; Regulation of gene expression; Regulator; Gene expression; Transcriptional regulation; Transcription factor; Transcription (linguistics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001610559,0.0004469076,0.0002601666,0.0001745615,0.0001427266,0.0003591808,0.0002082245,0.0002329781,0.000808486],"category_scores_gemma":[0.0001079115,0.0001259541,0.0003435146,0.0001140382,0.0002339279,0.0001809127,0.000266423,0.0003811992,0.0003962311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003991855,"about_ca_system_score_gemma":0.0002781221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001101069,"about_ca_topic_score_gemma":0.0009797328,"domain_scores_codex":[0.999782,0.00002902935,0.00001939127,0.00006971353,0.00005863026,0.00004113899],"domain_scores_gemma":[0.9998879,0.00001185474,0.00004346034,0.00001664948,0.00002139874,0.00001862936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004880341,0.000008611307,0.0003428193,0.00002848049,0.000002266307,0.00001788376,0.00000694354,0.0000361847,0.9989585,0.00003998244,0.00002956809,0.0004799918],"study_design_scores_gemma":[0.000005594898,0.000148264,0.01716287,0.00001181214,0.00001909027,0.0002003353,0.00005805694,0.00131857,0.9790689,0.0000452185,0.001953086,0.00000811235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887341,0.001255829,0.006839306,0.00012607,0.00002549869,0.00003652811,0.001316159,0.0002632423,0.001403235],"genre_scores_gemma":[0.9920956,0.0003839518,0.004087992,0.00008129124,0.000008300163,0.00003083826,0.001308917,0.00003187202,0.001971233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001101069,"threshold_uncertainty_score":0.002896309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003300127490109772,"score_gpt":0.2174828206632659,"score_spread":0.2141826931731561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}