{"id":"W4416574827","doi":"10.1128/mbio.03111-25","title":"Cathepsin B hyperactivation facilitates exosome release of CVB3 particles and exacerbation of acute pancreatitis by impairing lysosomal integrity and acidification","year":2025,"lang":"en","type":"article","venue":"mBio","topic":"Pancreatitis Pathology and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Priority Academic Program Development of Jiangsu Higher Education Institutions; National Natural Science Foundation of China","keywords":"Cathepsin B; Lysosome; Exosome; Acute pancreatitis; Internalization; Cathepsin; Exacerbation; Cathepsin L; Hyperactivation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001142036,0.00007991868,0.0002154868,0.00006668177,0.00004272055,0.0000042494,0.00001667794,0.00007286398,0.000007864391],"category_scores_gemma":[0.0001097965,0.00006963762,0.00002318688,0.00008938133,0.0001318341,0.00009984948,0.00001533125,0.00007593427,0.000001085881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003143158,"about_ca_system_score_gemma":0.00003379005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003155169,"about_ca_topic_score_gemma":0.000009466352,"domain_scores_codex":[0.9994405,0.0000582799,0.0002013637,0.0001571336,0.00006346349,0.00007927205],"domain_scores_gemma":[0.9995862,0.0001030923,0.00008512595,0.0001259644,0.00006511532,0.00003454196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001597544,0.0001362605,0.5332739,0.00009500859,0.0001200583,0.00000421244,0.0005087861,2.520854e-7,0.4558236,0.0007068848,0.00004769403,0.00912353],"study_design_scores_gemma":[0.0008003077,0.0001782505,0.633266,0.00009380742,0.0002122748,0.0000177784,0.0001338242,0.0001111982,0.3646015,0.0005252309,0.00002404587,0.00003580871],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973792,0.001121699,0.0003825783,0.0006148439,0.00001823361,0.0002118792,0.00006940133,0.0000182579,0.0001839134],"genre_scores_gemma":[0.9980717,0.0006254225,0.0009410769,0.00002591217,0.000004856787,0.00002398008,0.00008294878,0.000003616521,0.0002204593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09999204,"threshold_uncertainty_score":0.283974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0133307930008867,"score_gpt":0.2736176255737371,"score_spread":0.2602868325728505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}