{"id":"W4416576099","doi":"10.1101/2025.11.20.25340712","title":"Comprehensive genomic atlas of plasma proteome in the Japanese population: the Nagahama study","year":2025,"lang":"","type":"preprint","venue":"medRxiv","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Ministry of Health, Labour and Welfare","keywords":"Proteome; Biobank; Mendelian randomization; Genome-wide association study; Genome; Population; Quantitative trait locus; Blood proteins","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003774079,0.0003505562,0.0003046023,0.00160193,0.0006213102,0.0005872491,0.0002749339,0.0002303215,0.001342642],"category_scores_gemma":[0.0004084348,0.0002075721,0.0004736983,0.002678629,0.0001743268,0.0001493043,0.0008728714,0.0002330045,0.0002801447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003160492,"about_ca_system_score_gemma":0.0004797569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02216194,"about_ca_topic_score_gemma":0.0206347,"domain_scores_codex":[0.9998055,0.00003585441,0.00002006172,0.00008410065,0.00002544913,0.00002897018],"domain_scores_gemma":[0.9997705,0.00001309176,0.00005196503,0.00004896667,0.00005756411,0.00005800386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005221355,0.00003962887,0.9421248,0.0002724589,0.0007317062,0.0009749818,0.001798467,0.0002116347,0.02963583,0.0003433728,0.004573101,0.01877186],"study_design_scores_gemma":[0.00001127262,0.00001882876,0.995679,0.000009329237,0.0001617,0.000320294,0.0003524997,0.0001276065,0.0003830015,0.0001043519,0.002825779,0.000006361569],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856842,0.001352744,0.001338381,0.0001611687,0.00001783634,0.0000326348,0.0100724,0.00004144029,0.001299266],"genre_scores_gemma":[0.9817553,0.0009217719,0.002371168,0.0001068338,0.00003339925,0.00008823876,0.01362745,0.00003501791,0.0010609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02216194,"threshold_uncertainty_score":0.04406589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02543865262487518,"score_gpt":0.295204907440208,"score_spread":0.2697662548153328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}