{"id":"W4416576228","doi":"10.1038/s41409-025-02757-1","title":"Measurable residual mutated NPM1 before allogeneic transplant for acute myeloid leukemia","year":2025,"lang":"en","type":"article","venue":"Bone Marrow Transplantation","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; U.S. Navy; Genentech; Health Resources and Services Administration; National Institutes of Health; Syndax Pharmaceuticals; Office of Naval Research; Jazz Pharmaceuticals; AstraZeneca; Takeda Pharmaceuticals U.S.A.; Amgen; Bill and Melinda Gates Foundation; Foundation for the National Institutes of Health; Gilead Sciences; U.S. Department of Defense","keywords":"NPM1; Myeloid leukemia; Minimal residual disease; Transplantation; Leukemia; Myeloid; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006356849,0.0003880385,0.0006298386,0.0005245628,0.0002940575,0.0000546416,0.0002228249,0.0003516925,0.00008728536],"category_scores_gemma":[0.000047069,0.0003583323,0.00024812,0.0006388268,0.0001355112,0.0002107091,0.00001251214,0.0004414495,0.00004416458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007774996,"about_ca_system_score_gemma":0.001366549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002508298,"about_ca_topic_score_gemma":0.000446726,"domain_scores_codex":[0.9971998,0.0001124732,0.0006733551,0.0006739,0.0005752587,0.0007652482],"domain_scores_gemma":[0.9987355,0.0001924269,0.00009962061,0.0004281983,0.0003209399,0.0002233194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02233799,0.0002630361,0.01001463,0.003536789,0.002295013,0.001621829,0.002818835,0.0003276186,0.9144433,0.002278663,0.01370144,0.02636093],"study_design_scores_gemma":[0.04294882,0.002251775,0.1175723,0.002122715,0.008671332,0.002590448,0.00047295,0.006658935,0.8021869,0.003007384,0.01011649,0.001399924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9642277,0.0004689301,0.02155479,0.00438981,0.0003183192,0.00286983,0.0009022324,0.0003826147,0.004885806],"genre_scores_gemma":[0.9784887,0.001140438,0.00514147,0.0008852985,0.0001596248,0.0004912484,0.004037948,0.0000837729,0.009571533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1122563,"threshold_uncertainty_score":0.9998869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01584470072041708,"score_gpt":0.2951343406080215,"score_spread":0.2792896398876044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}