{"id":"W4416586312","doi":"10.1016/j.jid.2025.10.095","title":"091 Icotrokinra, a targeted oral peptide that selectively blocks the interleukin-23–receptor, for the treatment of moderate-to-severe plaque psoriasis: Results through Week 24 of the Phase 3, 
randomized, double-blind, placebo-controlled ICONIC-LEAD trial","year":2025,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Thomas Hospital; Innovaderm (Canada)","funders":"","keywords":"Plaque psoriasis; Placebo; Peptide; Phases of clinical research; Oral administration; Phase (matter)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001086415,0.001488989,0.001963504,0.0003162056,0.0003777809,0.000911184,0.0007035036,0.001373145,0.005289753],"category_scores_gemma":[0.0007801555,0.0003733807,0.001560688,0.0003674112,0.0008060299,0.0007257091,0.0002007418,0.002536117,0.001069699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005359854,"about_ca_system_score_gemma":0.000897938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001535112,"about_ca_topic_score_gemma":0.00354053,"domain_scores_codex":[0.9996891,0.0001235063,0.00001836682,0.00005684795,0.00002967034,0.00008258133],"domain_scores_gemma":[0.9995888,0.00009902351,0.00008222117,0.00003498998,0.000034765,0.0001602339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.938428,0.006471692,0.0006070947,0.001148802,0.001136928,0.00006723554,0.00005844517,0.0005156709,0.01159697,0.000207798,0.002555421,0.03720593],"study_design_scores_gemma":[0.9145402,0.07864242,0.003023802,0.00005491556,0.0007138088,0.0000636209,0.00002518813,0.0003672435,0.001204063,0.000154747,0.00118402,0.00002611467],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789214,0.01012487,0.001026051,0.0007101013,0.0004848163,0.00193285,0.001901065,0.0002750009,0.004623847],"genre_scores_gemma":[0.9813733,0.005694455,0.001549002,0.001455317,0.0003251617,0.001474708,0.002302035,0.00006421575,0.005761923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005289753,"threshold_uncertainty_score":0.01769602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05076106655039259,"score_gpt":0.3029761348135224,"score_spread":0.2522150682631298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}