{"id":"W4416599723","doi":"10.1007/s40268-025-00529-2","title":"Safety, Tolerability, Pharmacokinetics, and Viral Pharmacodynamics of the Monoclonal Antibody Sotrovimab Administered via Intramuscular Injection in Participants with Early, Mild-to-Moderate COVID-19: A Randomized Clinical Trial","year":2025,"lang":"en","type":"article","venue":"Drugs in R&D","topic":"Intramuscular injections and effects","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"GlaxoSmithKline (Canada); Etobicoke General Hospital","funders":"GlaxoSmithKline Biologicals; Vir Biotechnology","keywords":"Pharmacodynamics; Monoclonal antibody; Randomized controlled trial; Intramuscular injection; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003439643,0.001365039,0.001721526,0.0003287713,0.0003877477,0.0008252233,0.0006586369,0.001854538,0.004198997],"category_scores_gemma":[0.002970626,0.0006286264,0.0018227,0.0002719907,0.001203151,0.0009323446,0.000343909,0.002298674,0.000720381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006986497,"about_ca_system_score_gemma":0.0009112704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003250805,"about_ca_topic_score_gemma":0.0005868227,"domain_scores_codex":[0.9986075,0.0008661331,0.00009641449,0.0001864625,0.0001001915,0.0001433175],"domain_scores_gemma":[0.9980082,0.0005882696,0.0005668731,0.0001758983,0.0001420543,0.0005187653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9732392,0.01129259,0.001405617,0.0002260521,0.0005697184,0.00002442325,0.00004838433,0.0001486236,0.003344484,0.00006985432,0.0003115078,0.009319516],"study_design_scores_gemma":[0.7315168,0.2607321,0.004762831,0.00002593065,0.0006217515,0.00003928416,0.0000264653,0.0005740402,0.0009821242,0.0001573718,0.0005431258,0.00001813738],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945014,0.0009767015,0.0003554479,0.000263273,0.0001165321,0.002648232,0.0003450499,0.00003005676,0.0007632959],"genre_scores_gemma":[0.9939927,0.0005198844,0.0008131743,0.0004427722,0.0002064342,0.002896845,0.0003429868,0.000009933022,0.0007753106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004198997,"threshold_uncertainty_score":0.0181908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02778996596572109,"score_gpt":0.4006819742762227,"score_spread":0.3728920083105016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}