{"id":"W4416599723","doi":"10.1007/s40268-025-00529-2","title":"Safety, Tolerability, Pharmacokinetics, and Viral Pharmacodynamics of the Monoclonal Antibody Sotrovimab Administered via Intramuscular Injection in Participants with Early, Mild-to-Moderate COVID-19: A Randomized Clinical Trial","year":2025,"lang":"en","type":"article","venue":"Drugs in R&D","topic":"Intramuscular injections and effects","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"GlaxoSmithKline (Canada); Etobicoke General Hospital","funders":"GlaxoSmithKline Biologicals; Vir Biotechnology","keywords":"Pharmacodynamics; Monoclonal antibody; Randomized controlled trial; Intramuscular injection; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003728926,0.000262436,0.001119649,0.0003318472,0.0001069552,0.00003333241,0.0001546484,0.000175388,0.00002245035],"category_scores_gemma":[0.001190622,0.0001851137,0.0002609284,0.0006813318,0.0004549357,0.0000722207,0.0001449433,0.0006233936,0.000001509289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002193939,"about_ca_system_score_gemma":0.0005710656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008380105,"about_ca_topic_score_gemma":0.0002533931,"domain_scores_codex":[0.996124,0.001397414,0.001215398,0.0005210695,0.0003280911,0.000414006],"domain_scores_gemma":[0.9982967,0.0007896161,0.0001907046,0.0003866015,0.0001101918,0.0002261944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9365318,0.001815737,0.04555163,0.0004301999,0.0004951135,0.00003704081,0.002034194,0.005077972,0.001696825,0.0003577409,0.00005688729,0.005914793],"study_design_scores_gemma":[0.791355,0.001546487,0.03080386,0.0003902329,0.0007829746,0.0000279835,0.0002063324,0.1719895,0.001614927,0.0007216978,0.0002485337,0.0003125295],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855193,0.00009119314,0.007675109,0.001879447,0.000807061,0.003787855,0.00001662437,0.00002963496,0.0001937638],"genre_scores_gemma":[0.9976323,0.00008724182,0.0006170552,0.001272874,0.0001133499,0.000181931,0.00001914328,0.000021247,0.00005484571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1669115,"threshold_uncertainty_score":0.7548717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02778996596572109,"score_gpt":0.4006819742762227,"score_spread":0.3728920083105016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}