{"id":"W4416603707","doi":"10.5256/f1000research.23868.r66881","title":"Referee report. For: Null effect of circulating sphingomyelins on risk for breast cancer: a Mendelian randomization report using Breast Cancer Association Consortium (BCAC) data. [version 1; peer review: 2 approved with reservations]","year":2020,"lang":"en","type":"article","venue":"Faculty of 1000 Research Ltd","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Horizon 2020 Framework Programme; Government of Canada; Cancer Research UK; National Institutes of Health; European Commission; Canadian Institutes of Health Research; Genome Canada","keywords":"Mendelian randomization; Breast cancer; Allele; Association (psychology); Clinical trial; Randomization; Cancer; Case-control study","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.008943595,0.001225807,0.002278852,0.003380003,0.002079338,0.001716741,0.002965326,0.006741991,0.4588434],"category_scores_gemma":[0.1604571,0.000905853,0.002333375,0.002602506,0.0006317144,0.001191187,0.001893187,0.003830683,0.1749206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001931266,"about_ca_system_score_gemma":0.002837154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02136833,"about_ca_topic_score_gemma":0.02140592,"domain_scores_codex":[0.9957207,0.001246869,0.0007971817,0.0005594207,0.001398861,0.0002769752],"domain_scores_gemma":[0.9021753,0.04495041,0.002073422,0.006441437,0.04201771,0.002341811],"domain_codex":null,"domain_gemma":"evaluation","domain_candidate":"evaluation","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002490427,0.00001261981,0.00009199842,0.00005912645,0.00001057003,0.00009188416,0.00001710103,0.00001517585,0.00006469416,0.0003339156,0.9956552,0.003622795],"study_design_scores_gemma":[0.0005830185,0.00008105552,0.005991638,0.0005595693,0.0001015463,0.001074966,0.0001716672,0.0005230571,0.0004817796,0.01097592,0.9793066,0.000149123],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"commentary","genre_scores_codex":[0.001467425,0.00265554,0.01909324,0.3382068,0.4177029,0.003361716,0.1356543,0.008329231,0.07352884],"genre_scores_gemma":[0.01922392,0.003682125,0.04045513,0.2356451,0.1204081,0.009184911,0.06198819,0.00633634,0.5030762],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.9910564,"threshold_uncertainty_score":0.7718943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06463693003585985,"score_gpt":0.3871582884141934,"score_spread":0.3225213583783336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}