{"id":"W4416604888","doi":"10.5256/f1000research.23868.r61188","title":"Referee report. For: Null effect of circulating sphingomyelins on risk for breast cancer: a Mendelian randomization report using Breast Cancer Association Consortium (BCAC) data. [version 1; peer review: 1 approved with reservations]","year":2020,"lang":"en","type":"article","venue":"Faculty of 1000 Research Ltd","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Horizon 2020 Framework Programme; Government of Canada; Cancer Research UK; National Institutes of Health; European Commission; Canadian Institutes of Health Research; Genome Canada","keywords":"Mendelian randomization; Breast cancer; Allele; Association (psychology); Clinical trial; Randomization; Cancer; Case-control study","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00909358,0.001225276,0.002288206,0.003409513,0.00207959,0.001735366,0.002978191,0.006757156,0.4567088],"category_scores_gemma":[0.1622766,0.0009025077,0.002349137,0.002623088,0.0006373197,0.001194607,0.001893351,0.003871998,0.1757836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001970647,"about_ca_system_score_gemma":0.00289472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02154542,"about_ca_topic_score_gemma":0.02190073,"domain_scores_codex":[0.9956469,0.001266274,0.0008127763,0.0005625265,0.001431293,0.0002802204],"domain_scores_gemma":[0.9007203,0.04541434,0.002095609,0.006450615,0.04296438,0.002354761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002360783,0.00001210655,0.00008834073,0.00005804134,0.00001007745,0.00008627022,0.00001629466,0.00001468303,0.00006090371,0.0003241336,0.9957827,0.003522921],"study_design_scores_gemma":[0.0005612443,0.00007907347,0.005797181,0.0005627629,0.00009855589,0.001025273,0.0001694202,0.0005033692,0.0004635857,0.01078008,0.9798133,0.0001461804],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"commentary","genre_scores_codex":[0.001403541,0.002633318,0.01822326,0.3378436,0.4210572,0.003317895,0.1349513,0.008205119,0.0723647],"genre_scores_gemma":[0.01842118,0.00368867,0.03967273,0.2381209,0.1215524,0.009136966,0.06210132,0.006344299,0.5009616],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.4567088,"threshold_uncertainty_score":0.7749389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06620920492718833,"score_gpt":0.3876451110368931,"score_spread":0.3214359061097048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}