{"id":"W4416608523","doi":"10.1002/advs.202515042","title":"Parallel Genome‐Wide CRISPR Screens Reveal SORL1 and ZFYVE19 as Sequential Host Determinants of <i>Salmonella</i> Infection","year":2025,"lang":"en","type":"article","venue":"Advanced Science","topic":"Salmonella and Campylobacter epidemiology","field":"Agricultural and Biological Sciences","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Research Foundation of Korea","keywords":"CRISPR; Host (biology); Salmonella; Host factors; Salmonella infection; Gene; Experimental evolution","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006020818,0.0001617342,0.000296878,0.00004575096,0.0003573854,0.00003425993,0.0003368744,0.00008788853,0.00002364263],"category_scores_gemma":[0.0004134452,0.00007662019,0.00006690554,0.0008190781,0.0007021097,0.0003236221,0.0002128773,0.0001188741,0.00001130473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003438009,"about_ca_system_score_gemma":0.00004236005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007651895,"about_ca_topic_score_gemma":0.0004896384,"domain_scores_codex":[0.998361,0.00008472044,0.0003562467,0.0005558605,0.0001988162,0.0004433598],"domain_scores_gemma":[0.9991617,0.0002884041,0.0001736539,0.000118244,0.0001336939,0.0001243355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005110145,0.00003073442,0.3062996,0.000009860054,0.000003759985,0.000003826523,0.00002932139,0.000036896,0.6733842,0.0002705205,0.00003430005,0.0198458],"study_design_scores_gemma":[0.000187819,0.00024726,0.9561667,0.00003547248,0.00001286809,0.00001803621,0.00008147241,0.00008254992,0.03795152,0.002442022,0.002603205,0.0001710649],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966477,0.0003381867,0.00013569,0.0003507901,0.0002413909,0.0002104779,0.00001104068,0.00004334984,0.002021355],"genre_scores_gemma":[0.997903,0.0003786315,0.0005281786,0.0007012147,0.00004370991,0.00001223579,0.000004991892,8.79328e-7,0.000427147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6498671,"threshold_uncertainty_score":0.3124481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01803240400385682,"score_gpt":0.2889084277256933,"score_spread":0.2708760237218365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}