{"id":"W4416608523","doi":"10.1002/advs.202515042","title":"Parallel Genome‐Wide CRISPR Screens Reveal SORL1 and ZFYVE19 as Sequential Host Determinants of <i>Salmonella</i> Infection","year":2025,"lang":"en","type":"article","venue":"Advanced Science","topic":"Salmonella and Campylobacter epidemiology","field":"Agricultural and Biological Sciences","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Research Foundation of Korea","keywords":"CRISPR; Host (biology); Salmonella; Host factors; Salmonella infection; Gene; Experimental evolution","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002194824,0.0005130038,0.0004155495,0.0004293052,0.0001840911,0.0004690865,0.0003323751,0.0004039967,0.001591187],"category_scores_gemma":[0.0002138496,0.0002325509,0.0003856141,0.0001793883,0.0002996697,0.0001426284,0.0005733083,0.0005508221,0.0004511059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004629448,"about_ca_system_score_gemma":0.0003209849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001144654,"about_ca_topic_score_gemma":0.003084088,"domain_scores_codex":[0.999697,0.00002394577,0.00002360683,0.00009012596,0.00008942442,0.00007601876],"domain_scores_gemma":[0.999818,0.00003958002,0.00006053847,0.00001888287,0.0000171705,0.00004581434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009903701,0.0000282424,0.0003626247,0.00002212243,0.000009192657,0.00007335783,0.00001122101,0.0002423036,0.996156,0.0001331799,0.00006866848,0.002794176],"study_design_scores_gemma":[0.00002462965,0.0003119694,0.006259019,0.000007585148,0.00003199252,0.0003856796,0.00003947871,0.002481089,0.9875296,0.00008251495,0.002830706,0.00001571829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979784,0.0005560953,0.01383466,0.0001417968,0.00003215731,0.00008534994,0.00168213,0.0005439045,0.003339841],"genre_scores_gemma":[0.9821488,0.0004790644,0.009909464,0.0001607558,0.000005589801,0.00006528047,0.001691087,0.0001186597,0.005421279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001591187,"threshold_uncertainty_score":0.005322993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01803240400385682,"score_gpt":0.2889084277256933,"score_spread":0.2708760237218365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}