{"id":"W4416624684","doi":"10.1016/j.freeradbiomed.2025.11.027","title":"Mutant p53 disrupts antioxidant defense in fallopian tube epithelium via GSTAs suppression: A pathway to serous tubal carcinogenesis","year":2025,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Congressionally Directed Medical Research Programs; Division of Loan Repayment; National Cancer Institute; National Institutes of Health; Sylvester Comprehensive Cancer Center, University of Miami Health Systems; University of Miami; Foundation for Women's Cancer; Chan Zuckerberg Initiative; U.S. Department of Defense","keywords":"Fallopian tube; Serous fluid; Carcinogenesis; Neoplastic transformation; Epithelium; DNA damage; Genome instability; Malignant transformation; Ovary","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001370936,0.0002847961,0.000167182,0.0003631858,0.0002027776,0.0003361749,0.0002389318,0.0003451461,0.002029554],"category_scores_gemma":[0.0002086383,0.0001627165,0.0003441591,0.0001774266,0.000357236,0.0002360838,0.0002128484,0.0005344997,0.0002489138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002365886,"about_ca_system_score_gemma":0.0003255342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006729827,"about_ca_topic_score_gemma":0.0007518135,"domain_scores_codex":[0.9998944,0.00002682548,0.00001067771,0.00001742511,0.00002546548,0.0000250711],"domain_scores_gemma":[0.99988,0.0000161905,0.00003832786,0.00002354271,0.00001221123,0.00002973802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002336876,0.00004024245,0.0005278031,0.00002359382,0.000009636971,0.000159949,0.00001796374,0.00006057607,0.9971243,0.0003686586,0.00004675999,0.001386903],"study_design_scores_gemma":[0.00003031503,0.0003070654,0.004582161,0.000006113112,0.00002873883,0.00053511,0.00005858463,0.0009505466,0.9914621,0.0002041212,0.001831482,0.000003686609],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960736,0.0005471632,0.002094655,0.0002613547,0.00004926822,0.00001767784,0.0001217016,0.0001144758,0.0007201439],"genre_scores_gemma":[0.9979901,0.0002766595,0.0005729217,0.00003406199,0.000004295485,0.000006591528,0.00006967837,0.00001115676,0.001034599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002029554,"threshold_uncertainty_score":0.006789565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01220205888934633,"score_gpt":0.2973064859557457,"score_spread":0.2851044270663993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}